authors
- Martin J Sadowski, MD, PD
- Sigurdsson, Einar M
- Wisniewski, Thomas
- Pankiewicz, Joanna
- Scholtzova, Henrieta
- Ripellino, James A
- Li, Yongsheng
- Schmidt, Stephen D
- Mathews, Paul M
- Fryer, John D
- David M. Holtzman, MD
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
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Overview
publication date
- January 2004
published in
has subject area
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Apolipoproteins E
- Astrocytes
- Binding Sites
- Blood-Brain Barrier
- Brain
- Competitive Bidding
- Female
- Half-Life
- Humans
- Male
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Neuroblastoma
- Peptide Fragments
- Presenilin-1
- Protein Binding
- Tumor Cells, Cultured