Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
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Overview
publication date
- January 1, 2006
published in
- Journal of leukocyte biology Journal
has subject area
- Adult
- Age Factors
- Aged
- Aging
- Apoptosis
- Chemotaxis, Leukocyte
- Down-Regulation
- Enzyme Inhibitors
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Immunity, Cellular
- Intracellular Signaling Peptides and Proteins
- Membrane Microdomains
- Neutrophils
- Phosphorylation
- Protein Phosphatase 1
- Protein Transport
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases
- Reactive Oxygen Species
- Serine
- Tyrosine
- src-Family Kinases