GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.
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Overview
publication date
- January 1, 2006
published in
- Biogerontology Journal
has subject area
- Adult
- Aged
- Aged, 80 and over
- Aging
- Apoptosis
- Caspase 3
- Cell Survival
- Cells, Cultured
- Cysteine Proteinase Inhibitors
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Janus Kinase 2
- Neutrophils
- Oligopeptides
- Phosphorylation
- Protein Kinase Inhibitors
- Recombinant Proteins
- STAT Transcription Factors
- STAT3 Transcription Factor
- STAT5 Transcription Factor
- Signal Transduction
- Time Factors
- Tyrphostins