ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.
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Amyloid Precursor Protein Secretases
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antineoplastic Combined Chemotherapy Protocols
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Breast Neoplasms
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Cell Death
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Drug Evaluation, Preclinical
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Drug Resistance, Neoplasm
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Enzyme Inhibitors
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Gene Expression Regulation, Neoplastic
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Humans
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RNA, Small Interfering
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Receptor, ErbB-2
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Receptor, Notch1
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Trastuzumab
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Tumor Cells, Cultured
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Up-Regulation
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