Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
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Animals
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CD4-Positive T-Lymphocytes
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Cell Line, Tumor
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Cyclin D3
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinase 6
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Cyclins
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G1 Phase
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Gene Expression Regulation, Leukemic
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Gene Expression Regulation, Neoplastic
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Humans
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Lymphoma, T-Cell
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Mice
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Mice, Inbred C57BL
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NF-kappa B
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Phosphorylation
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Promoter Regions, Genetic
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Proto-Oncogene Proteins
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Receptor, Notch1
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Receptor, Notch2
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Receptor, Notch3
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Receptor, Notch4
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Receptors, Notch
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Retinoblastoma Protein
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S Phase
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Signal Transduction
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