An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
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Overview
publication date
- January 1, 2009
published in
- Biochemistry Journal
has subject area
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Benzodiazepinones
- Biocatalysis
- CHO Cells
- Cricetinae
- Cricetulus
- Dipeptides
- Fenofibrate
- Flurbiprofen
- Humans
- Kinetics
- Microsomes
- Nerve Tissue Proteins
- Peptide Fragments
- Protease Inhibitors
- Recombinant Proteins
- Substrate Specificity
- Transfection