authors
- Dudley Lamming, PhD
- Ahima, Rexford S
- Guertin, David A
- Sabatini, David M
- Baur, Joseph A
- Ye, Lan
- Katajisto, Pekka
- Goncalves, Marcus D
- Saitoh, Maki
- Stevens, Deanna M
- Davis, James G
- Salmon, Adam B
- Richardson, Arlan
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
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Overview
publication date
- January 1, 2012
published in
- Science (New York, N.Y.) Journal
has subject area
- Adipose Tissue, White
- Animals
- Carrier Proteins
- Female
- Gluconeogenesis
- Glucose
- Glucose Clamp Technique
- Homeostasis
- Insulin
- Insulin Resistance
- Liver
- Longevity
- Male
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Inbred C57BL
- Multiprotein Complexes
- Muscle, Skeletal
- Phosphorylation
- Proteins
- Proto-Oncogene Proteins c-akt
- Rapamycin-Insensitive Companion of mTOR Protein
- Signal Transduction
- Sirolimus
- TOR Serine-Threonine Kinases