authors
- Tsunemi, Taiji
- Al La Spada, MD, PhD
- Ashe, Travis D
- Morrison, Bradley E
- Soriano, Kathryn R
- Au, Jonathan
- Roque, Ruben A Vázquez
- Lazarowski, Eduardo R
- Damian, Vincent A
- Masliah, Eliezer
PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
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Overview
publication date
- January 1, 2012
published in
- Science translational medicine Journal
has subject area
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Huntington Disease
- Mice
- Mice, Transgenic
- Mitochondria
- Nerve Degeneration
- Oxidative Stress
- Peptides
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Phenotype
- Protein Structure, Quaternary
- Reactive Oxygen Species
- Trans-Activators
- Transcription Factors
- Transcriptional Activation
- Trinucleotide Repeat Expansion