5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.
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Overview
publication date
- January 2012
published in
- Annals of neurology Journal
has subject area
- ADAM Proteins
- ADAM10 Protein
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Arachidonate 5-Lipoxygenase
- Aspartic Acid Endopeptidases
- Brain
- Cells, Cultured
- Cyclin-Dependent Kinase 5
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Humans
- Maze Learning
- Membrane Proteins
- Memory Disorders
- Mice
- Mice, Transgenic
- NFI Transcription Factors
- Peptide Fragments
- Phosphorylation
- Presenilin-1
- Radioimmunoassay
- Random Allocation
- Signal Transduction
- Transfection
- tau Proteins