authors
- Howlett, Evan H
- Sanders, Laurie H
- Jensen, Nicholas
- Belmonte, Frances
- Zafar, Faria
- Hu, Xiaoping
- Kluss, Jillian
- Schüle, Birgitt
- Kaufman, Brett A
- Greenamyre, J T
LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
- Overview
- Identity
- Additional Document Info
- View All
Overview
publication date
- November 15, 2017
published in
- Human molecular genetics Journal
has subject area
- Adult
- Aged
- Aged, 80 and over
- Animals
- Cells, Cultured
- DNA Damage
- DNA, Mitochondrial
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Mesencephalon
- Middle Aged
- Mitochondria
- Morpholines
- Mutation
- Neurons
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Protein Kinase Inhibitors
- Pyrimidines
- Rats
- Rats, Sprague-Dawley