authors
- Pace, Michael C
- Xu, Guilian
- Fromholt, Susan
- Howard, John
- Crosby, Keith
- Giasson, Benoit I
- Lewis, Jada
- Borchelt, David R
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
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Overview
publication date
- January 1, 2018
published in
- Acta neuropathologica Journal
has subject area
- Age Factors
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Central Nervous System
- Chromatography, High Pressure Liquid
- Disease Models, Animal
- Female
- Humans
- Male
- Mice
- Mice, Transgenic
- Mutation
- Neurodegenerative Diseases
- Neurofibrillary Tangles
- Presenilin-1
- Protein Folding
- Proteome
- Solubility
- Tandem Mass Spectrometry
- alpha-Synuclein
- tau Proteins