Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy.
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publication date
- August 28, 2020
published in
has subject area
- Adenosine Triphosphate
- Alzheimer Disease
- Amyloid beta-Peptides
- Brain-Derived Neurotrophic Factor
- Disease Progression
- Exercise
- Forkhead Box Protein O1
- Humans
- Mitochondria
- Mitochondrial Diseases
- Mitophagy
- NAD
- Niacinamide
- Nicotinamide Mononucleotide
- Protein Kinases
- Pyridinium Compounds
- Reactive Oxygen Species
- Sirtuin 1
- Ubiquitin-Protein Ligases