SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease.
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Overview
publication date
- January 1, 2021
published in
has subject area
- Animals
- Ataxia
- Biomarkers
- DNA Helicases
- DNA-Directed DNA Polymerase
- Disease Susceptibility
- Exosomes
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genomic Instability
- Humans
- Motor Neuron Disease
- Multifunctional Enzymes
- Mutation
- Neurodegenerative Diseases
- RNA Helicases
- RNA Polymerase II
- RNA Stability
- S Phase
- S Phase Cell Cycle Checkpoints
- Stress Granules
- Sumoylation