Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function.
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Overview
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Keywords
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ACE2, Angiotensin-converting enzyme 2
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CLP, cecal ligation and puncture
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COVID-19, Coronavirus disease 2019
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EXT, Exostosin
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EXTL, Exostosin-like glycosyltransferase
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FFP, Fresh frozen plasma
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FGF, Fibroblast growth factor
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FGFR1, Fibroblast growth factor receptor 1
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GAG, Glycosaminoglycan
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GPC, Glypican
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Gal, Galactose
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GlcA, Glucuronic acid
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GlcNAc, N-actetyl glucosamine
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Glycocalyx
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HLMVEC, Human lung microvascular endothelial cell
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HS, Heparan sulfate
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HS2ST, Heparan sulfate 2-O-sulfotransferase
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HS3ST, Heparan sulfate 3-O-sulfotransferase
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HS6ST, Heparan sulfate 6-O-sulfotransferase
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HSPG, Heparan sulfate proteoglycan
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HUVEC, Human umbilical vein endothelial cell
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Heparan sulfate proteoglycan
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LPS, lipopolysaccharide
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NDST, N-deacetylase/N-sulfotransferase
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SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
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SDC, Syndecan
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Sulf, Endosulfatase
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Sulfation
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Synthesis
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TNFα, Tumor necrosis factor alpha
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UA, Hexuronic acid
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VEGF, Vascular endothelial growth factor
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Vascular endothelium
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XYLT, Xylosyltransferase
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Xyl, Xylose
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eGCX, Endothelial glycocalyx
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eNOS, Endothelial nitric oxide synthase
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