PROTEOMIC ANALYSIS OF FACTORS INVOLVED IN PCD PHENOTYPES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in learning how brain cells die in inherited neurodegenerative diseases. By understanding how the genes underlying these diseases work normally, we can understand how the defective gene leads to the disease, and subsequently design treatments. One of our models for neurodegenerative processes is the mouse Purkinje cell degeneration (pcd) mutation. We are attempting to understand how this gene works by 1) finding out what other proteins bind to it normally, and 2) identifying how loss of pcd function affects the proteins found within cells. We hope our results will contribute to the overall understanding of cell death in these devastating diseases.

Clin-STAR Database