Member of
- Program in Microbiome Dynamics Clinical Research Director 2021 -
- Center for Microbiome Research Clinical Director 2018 -
- Contact Info
- Websites
John P. Haran, MD, PhD
Positions
- Associate Professor, University of Massachusetts Medical School
Location
-
Worcester, MA
Clinical Disciplines
GEMSSTAR awardee
- Affiliation
- Publications
- Research
- Other
- View All
Affiliation
Publications
Selected Publications
-
article
- Probing the neurocardiac circuit in trauma and posttraumatic stress.. Journal of psychiatric research. 173-181. 2024
- The human gut microbiome and aging.. Gut microbes. 16:-. 2024
- Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study.. Psychological medicine. 1-11. 2024
- Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning.. Journal of anxiety disorders. -. 2024
- Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.. Biological psychiatry. Cognitive neuroscience and neuroimaging. 9:668-680. 2024
- Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk.. Frontiers in psychiatry. -. 2024
- Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure.. Translational psychiatry. 13:-. 2023
- Effectiveness of a bivalent mRNA vaccine dose against symptomatic SARS-CoV-2 infection among U.S. Healthcare personnel, September 2022-May 2023.. Vaccine. 42:2543-2552. 2023
- Effectiveness of a Messenger RNA Vaccine Booster Dose Against Coronavirus Disease 2019 Among US Healthcare Personnel, October 2021-July 2022.. Open forum infectious diseases. 10:-. 2023
- Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice.. Nature communications. 14:-. 2023
- Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.. JAMA network open. 6:-. 2023
- Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.. Psychological medicine. 54:338-349. 2023
- Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure.. Molecular psychiatry. 28:5140-5149. 2023
- Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure.. JAMA psychiatry. 80:220-229. 2023
- Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.. Biological psychiatry global open science. 3:705-715. 2023
- Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study.. BMJ open. 13:-. 2023
- Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure.. Molecular psychiatry. 28:2975-2984. 2023
- Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood.. Epidemiology and psychiatric sciences. -. 2023
- Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort.. Translational psychiatry. 13:-. 2023
- Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision.. Annals of emergency medicine. 81:249-261. 2022
- Oropharyngeal microbiome profiled at admission is predictive of the need for respiratory support among COVID-19 patients.. Frontiers in microbiology. -. 2022
- Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study.. PloS one. 17:-. 2022
- Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42:6593-6604. 2022
- Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.. Translational psychiatry. 12:-. 2022
- The Urinary Microbiome of Older Adults Residing in a Nursing Home Varies With Duration of Residence and Shows Increases in Potential Pathogens.. The journals of gerontology. Series A, Biological sciences and medical sciences. 77:1313-1320. 2022
- Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.. The American journal of psychiatry. 179:661-672. 2022
- Oropharyngeal Microbiome Profiled at Admission is Predictive of the Need for Respiratory Support Among COVID-19 Patients.. medRxiv : the preprint server for health sciences. 2022
- Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma.. Psychological medicine. 53:1-10. 2022
- Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.. Gut. 71:2233-2252. 2022
- Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study.. Depression and anxiety. 39:56-70. 2021
- Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision.. JAMA psychiatry. 78:1228-1237. 2021
- Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.. JCI insight. 6. 2021
- Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.. The American journal of psychiatry. 178:1037-1049. 2021
- The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and Is Influenced by Medication Exposures, Age, Environment, and Frailty.. The journals of gerontology. Series A, Biological sciences and medical sciences. 76:1930-1938. 2021
- Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel.. The New England journal of medicine. 385:-. 2021
- A prospective examination of sex differences in posttraumatic autonomic functioning.. Neurobiology of stress. -. 2021
- Classification and Prediction of Post-Trauma Outcomes Related to PTSD Using Circadian Rhythm Changes Measured via Wrist-Worn Research Watch in a Large Longitudinal Cohort.. IEEE journal of biomedical and health informatics. 25:2866-2876. 2021
- Correction: The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.. Molecular psychiatry. 26:-. 2021
- Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel - 33 U.S. Sites, January-March 2021.. MMWR. Morbidity and mortality weekly report. 70:753-758. 2021
- Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study.. Trials. 22:-. 2021
- Prior sleep problems and adverse post-traumatic neuropsychiatric sequelae of motor vehicle collision in the AURORA study.. Sleep. 44. 2021
- Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 46:1263-1271. 2021
- Clostridioides difficile. Gut microbes. 13:1-15. 2021
- Aging, Frailty, and the Microbiome-How Dysbiosis Influences Human Aging and Disease.. Gastroenterology. 160:507-523. 2020
- Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study.. Psychological medicine. 52:1-14. 2020
- Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study.. Molecular psychiatry. 26:3108-3121. 2020
- Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections.. Annals of emergency medicine. 76:56-66. 2020
- The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.. Molecular psychiatry. 25:283-296. 2019
- Clostridium difficile. Gut pathogens. -. 2019
- Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway.. mBio. 10. 2019
- Deviating from IDSA treatment guidelines for non-purulent skin infections increases the risk of treatment failure in emergency department patients.. Epidemiology and infection. -. 2018
- Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department.. The Journal of emergency medicine. 55:347-353. 2018
- The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location.. Journal of medical microbiology. 67:40-51. 2017
- Medication Exposure and Risk of Recurrent Clostridium difficile Infection in Community-Dwelling Older People and Nursing Home Residents.. Journal of the American Geriatrics Society. 66:333-338. 2017
- Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections.. The American journal of emergency medicine. 35:249-254. 2016
- Antibiotic-associated diarrhoea in emergency department observation unit patients.. Epidemiology and infection. 144:2176-83. 2016
- Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice.. The American journal of emergency medicine. 33:1780-5. 2015
- Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics.. The American journal of emergency medicine. 32:1195-9. 2014
- Antigen-specific H1N1 influenza antibody responses in acute respiratory tract infections and their relation to influenza infection and disease course.. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 60:367-73. 2014
- A case of neck pain: The presentation of Chairi 1 malformations in children.. Journal of emergencies, trauma, and shock. 7:32-4. 2014
- All purulence is local - epidemiology and management of skin and soft tissue infections in three urban emergency departments.. BMC emergency medicine. -. 2013
- Immunization with cross-conserved H1N1 influenza CD4+ T-cell epitopes lowers viral burden in HLA DR3 transgenic mice.. Human vaccines & immunotherapeutics. 9:2060-8. 2013
- A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial.. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 20:584-91. 2013
- Cytokine markers as predictors of type of respiratory infection in patients during the influenza season.. The American journal of emergency medicine. 31:816-21. 2013
- C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness.. The American journal of emergency medicine. 31:137-44. 2012
- Correlation of C-reactive protein to severity of symptoms in acute influenza A infection.. Journal of emergencies, trauma, and shock. 5:149-52. 2012
- Paecilomyces lilacinus olecranon bursitis in an immunocompromised host: case report and review.. Diagnostic microbiology and infectious disease. 61:354-7. 2008
- Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals.. AIDS research and human retroviruses. 18:577-83. 2002
Research
Research Overview
-
Our current research focuses on three main areas:
- Understanding the “Microbiome-gut-brain axis” in Alzheimer’s disease and its role in cognitive decline
- Investigating the gut microbiome's composition as we age and how dysbiosis can lead to risk of drug resistant organism and Clostridioides difficile colonization and infection among nursing home residents
- Care of Emergency Department patients presenting after a traumatic event and the risk of developing post-traumatic neuropsychiatric disorders. This includes novel therapies to prevent disease and investigations into how dysbiosis of the gut microbiome can increase the risk of post-traumatic stress disorder.
Our current COVID-19 research focuses on three main areas:
- The microbiome’s role in acute SARS-CoV-2 infection and disease severity including trials using novel microbiome-based treatments to improve outcomes
- COVID-19 vaccine efficacy among healthcare workers
- The oral and gut microbiome's role in COVID-19 outcomes focusing on the risk of developing long-COVID
Principal Investigator on
- Aging Microbiome, Immunosenescence, and risk of Multi-drug Resistant Organism Colonization and Infection in the Nursing Home 2023 - 2027
- Understanding the Microbiome-gut-brain axisn Alzheimer disease and its Role in Cognitive Decline 2020 - 2024
- The elderly gut microbiome during transition to long-term care and the risk of Clostridium difficile carriage 2018 - 2022
- Study of the Intestinal Microbiome, Antimicrobial Use, and Clostridium difficile Infections in Long-term Care Facility Residents 2017 - 2020
Co-Investigator on
Keywords
- Alzheimer's Disease
- Gut-brain axis
- Microbiome
- Nursing Home