Head of
- Memory Disorders Program 2008 -
- Contact Info
- 2026877337
- Websites
Raymond Scott Turner, MD, PhD
Positions
- Professor, Georgetown University
Location
-
Washington, D.C. 20057
U.S.A.
Clinical Disciplines
Beeson awardee
- Affiliation
- Publications
- Research
- Other
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Affiliation
Publications
Selected Publications
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article
- Aging as a target for the prevention and treatment of Alzheimer's disease.. Frontiers in neurology. -. 2024
- Screening for Cognitive Decline in Isolated/Idiopathic REM Sleep Behavior Disorder: Which Test Is Best?. Neurology. 102:-. 2024
- Resveratrol differentially affects MMP-9 release from neurons and glia; implications for therapeutic efficacy.. Journal of neurochemistry. 2024
- An explainable machine learning model of cognitive decline derived from speech.. Alzheimer's & dementia (Amsterdam, Netherlands). 15:-. 2023
- Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S98-S114. 2023
- Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S29-S41. 2023
- A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment.. Annals of clinical and translational neurology. 10:1738-1748. 2023
- Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S49-S63. 2023
- Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S115-S125. 2023
- White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS).. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S89-S97. 2023
- Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S42-S48. 2023
- Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S8-S18. 2023
- Learning slopes in early-onset Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19 Suppl 9:S19-S28. 2023
- CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.. Neurobiology of disease. 2023
- Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023
- Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer's disease.. Journal of neuroinflammation. 2023
- Matrix disequilibrium in Alzheimer's disease and conditions that increase Alzheimer's disease risk.. Frontiers in neuroscience. 2023
- Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023
- The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023
- Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.. The New England journal of medicine. 2023
- Increasing access to cognitive screening in the elderly: Applying natural language processing methods to speech collected over the telephone.. Cortex; a journal devoted to the study of the nervous system and behavior. 26-38. 2022
- Corrigendum: A 5-min Cognitive Task With Deep Learning Accurately Detects Early Alzheimer's Disease.. Frontiers in aging neuroscience. -. 2022
- Class-Based Antiretroviral Exposure and Cognition Among Women Living with HIV.. AIDS research and human retroviruses. 38:561-570. 2022
- Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease.. Frontiers in neurology. 2022
- Class-Based Antiretroviral Exposure and Cognition Among Women Living with HIV.. AIDS research and human retroviruses. 2022
- Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies.. Alzheimer's & dementia (New York, N. Y.). 2022
- Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer's disease.. PloS one. 16:-. 2021
- Low CD4+ cell count nadir exacerbates the impacts of APOE ε4 on functional connectivity and memory in adults with HIV.. AIDS (London, England). 35:727-736. 2021
- Acceptability of collecting speech samples from the elderly via the telephone. DIGITAL HEALTH. 2021
- Low CD4 nadir exacerbates the impacts of APOE ε4 on functional connectivity and memory in adults with HIV.. AIDS (London, England). 2021
- Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer's Disease.. Aging and disease. 2021
- Research Attitudes Questionnaire scores predict Alzheimer's disease clinical trial dropout.. Clinical trials (London, England). 2021
- A 5-min Cognitive Task With Deep Learning Accurately Detects Early Alzheimer's Disease.. Frontiers in aging neuroscience. -. 2020
- Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease.. Annals of neurology. 88:183-194. 2020
- Potential New Approaches for Diagnosis of Alzheimer's Disease and Related Dementias. Frontiers in neurology. 2020
- Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.. JAMA neurology. 2019
- Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 36:-. 2018
- Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018
- Long-Term maintenance of anomia treatment effects in primary progressive aphasia.. Neuropsychological rehabilitation. 2018
- (11)C-PBR28 PET detects translocator protein in a patient with astrocytoma and Alzheimer disease. 2017
- Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing. 2017
- Resveratrol for Alzheimer's disease.. Annals of the New York Academy of Sciences. 2017
- Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. 2017
- The BIOCARD Index: A Summary Measure to Predict Onset of Mild Cognitive Impairment. 2017
- The BIOCARD Index: A Summary Measure to Predict Onset of Mild Cognitive Impairment.. Alzheimer disease and associated disorders. 31:114-119. 2017
- An individual with human immunodeficiency virus, dementia, and central nervous system amyloid deposition.. Alzheimer's & dementia (Amsterdam, Netherlands). 1-5. 2016
- (11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease. 2016
- Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease. 2016
- Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway. Biochimica Et Biophysica Acta-Biomembranes. 2016
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.. Neurology. 2015
- NILOTINIB AND BOSUTINIB MODULATE PRE-PLAQUE ALTERATIONS OF BLOOD IMMUNE MARKERS AND NEURO-INFLAMMATION IN ALZHEIMER'S DISEASE MODELS. Neuroscience. 2015
- A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease 2014
- Cognitive Changes Preceding Clinical Symptom Onset of Mild Cognitive Impairment and Relationship to ApoE Genotype. Current Alzheimer Research. 2014
- Cognitive Impairment in Older Patients With Breast Cancer Before Systemic Therapy: Is There an Interaction Between Cancer and Comorbidity?. Journal of Clinical Oncology. 2014
- Corrigendum to "A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease" [Exp. Neurol. 252 (2014) 105-113] 2014
- Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration. 2014
- A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013
- Age-related loss of noradrenergic neurons in the brains of triple transgenic mice 2013
- Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking 2013
- Coexisting adult polyglucosan body disease with frontotemporal lobar degeneration with transactivation response DNA-binding protein-43 (TDP-43)-positive neuronal inclusions 2013
- Cognitive Effects of Cancer and Its Treatments at the Intersection of Aging: What Do We Know; What Do We Need to Know?. Seminars in Oncology. 2013
- Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease 2013
- In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain : a journal of neurology. 2013
- Mercaptoacetamide-based class II HDAC inhibitor lowers A beta levels and improves learning and memory in a mouse model of Alzheimer's disease 2013
- Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study 2011
- ApoE Receptor 2 Regulates Synapse and Dendritic Spine Formation 2011
- Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice 2011
- Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors 2011
- ApoE mimetic peptide decreases A beta production in vitro and in vivo. Molecular Neurodegeneration. 2010
- Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines 2010
- The cytoplasmic adaptor protein X11 alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. Faseb Journal. 2010
- Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease 2010
- Validation of consensus panel diagnosis in dementia 2010
- Amyloid-β-induced ion flux in artificial lipid bilayers and neuronal cells: Resolving a controversy 2009
- ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo 2009
- X11α haploinsufficiency enhances Aβ amyloid deposition in Alzheimer's disease transgenic mice 2009
- FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease 2007
- Alzheimer's disease 2006
- A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging 2004
- Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? 2004
- X11α impairs γ- but not β-cleavage of amyloid precursor protein 2004
- Biomarkers of Alzheimer's disease and mild cognitive impairment: Are we there yet? 2003
- X11α modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: Mutational analysis of the YENPTY sequence 2003
- ELISA analysis of β-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways 2002
- Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies 2002
- Inherited dementias 2002
- Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease 2002
- Spontaneous intracranial hypotension causing reversible frontotemporal dementia 2002
- Stable β-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice 2002
- Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism 2002
- Alzheimer's disease in man and transgenic mice: Females at higher risk 2001
- The Protease Inhibitor, MG132, Blocks Maturation of the Amyloid Precursor Protein Swedish Mutant Preventing Cleavage by β-Secretase 2001
- Modulation of amyloid precursor protein metabolism by X11α/Mint-1: A deletion analysis of protein-protein interaction domains 2000
- The pathology of REM sleep behavior disorder with comorbid Lewy body dementia 2000
- What Persian Gulf War Syndrome? 2000
- Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol 1999
- Molecular analysis of the X11-mLin-2/CASK complex in brain 1999
- GABA(A) receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells 1998
- Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting 1998
- The X11α protein slows cellular amyloid precursor protein processing and reduces aβ40 and aβ42 secretion 1998
- The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Aβ40 and Aβ42 secretion 1998
- X11 interaction with β-amyloid precursor protein modulates its cellular stabilization and reduces amyloid β-protein secretion 1998
- Probable diffuse Lewy body disease presenting as REM sleep behavior disorder 1997
- Amyloids β40 and β42 are generated intracellularly in cultured human neurons and their secretion increases with maturation 1996
- Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia 1996
- Vaccinia virus serves as an efficient vector for expressing heterologous proteins in human NTera 2 neurons 1996
- Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular β-amyloid or A4 peptides 1993
- PHOSPHOLIPID CALCIUM-DEPENDENT PROTEIN-KINASE (PROTEIN-KINASE-C) SYSTEM - A MAJOR SITE OF BIOREGULATION 1986
- SYNTHETIC MYELIN BASIC-PROTEIN PEPTIDE ANALOGS ARE SPECIFIC INHIBITORS OF PHOSPHOLIPID CALCIUM-DEPENDENT PROTEIN-KINASE (PROTEIN-KINASE-C) 1986
- SUBSTRATE-SPECIFICITY OF PHOSPHOLIPID/CA-2+-DEPENDENT PROTEIN-KINASE AS PROBED WITH SYNTHETIC PEPTIDE-FRAGMENTS OF THE BOVINE MYELIN BASIC-PROTEIN 1985
- DEVELOPMENTAL STUDIES OF PHOSPHOLIPID-SENSITIVE CA2+-DEPENDENT PROTEIN-KINASE AND ITS SUBSTRATES AND OF PHOSPHOPROTEIN PHOSPHATASES IN RAT-BRAIN 1984
- PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE - A MAJOR PROTEIN-PHOSPHORYLATION SYSTEM 1984
- PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE INHIBITION BY R-24571, A CALMODULIN ANTAGONIST 1984
- Phospholipid‐Sensitive Ca2+‐Dependent Protein Kinase Preferentially Phosphorylates Serine‐115 of Bovine Myelin Basic Protein. Journal of Neurochemistry. 1984
- S-100 AND OTHER ACIDIC PROTEINS PROMOTE CA-2+-INDEPENDENT PHOSPHORYLATION OF PROTAMINE CATALYZED BY A NEW PROTEIN-KINASE FROM BRAIN 1984
- COBRA POLYPEPTIDE CYTOTOXIN-I AND MARINE WORM POLYPEPTIDE CYTOTOXIN-A-IV ARE POTENT AND SELECTIVE INHIBITORS OF PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE 1983
- COMPARATIVE ABILITIES OF LANTHANIDE IONS LA-3+ AND TB-3+ TO SUBSTITUTE FOR CA-2+ IN REGULATING PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE AND MYOSIN LIGHT CHAIN KINASE 1983
- POLYAMINES INHIBIT PHOSPHOLIPID-SENSITIVE AND CALMODULIN-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASES 1983
- BASIC-PROTEIN IN BRAIN MYELIN IS PHOSPHORYLATED BY ENDOGENOUS PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE 1982
- INHIBITION BY MELITTIN OF PHOSPHOLIPID-SENSITIVE AND CALMODULIN-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASES 1982
- PHOSPHOLIPID-SENSITIVE CA-2+-DEPENDENT PROTEIN-KINASE FROM HEART .2. SUBSTRATE-SPECIFICITY AND INHIBITION BY VARIOUS AGENTS 1982
- METHIONINE-ENKEPHALIN AND MORPHINE - AMOUNT EJECTED MICRO-IONTOPHORETICALLY 1981
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document
- Inhibition of discoidin domain receptor (DDR)-1 with nilotinib induces autophagy and reduces inflammation and vascular fibrosis in Alzheimer’s disease 2023
- CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice 2022
- Spatial inhibition of return is impaired in mild cognitive impairment and mild Alzheimer’s disease 2020
Research
Principal Investigator on
- Druggable regulators of nitric oxide production as new Alzheimer's disease therap 2012 - 2014
- Mechanism of Abeta Sequestration 2007 - 2012
- SAFETY AND EFFECTIVENES OF IMMUNE GLOBULIN INTRAVENOUS 2009 - 2010
- DISTRIBUTION OF VOLTAGE-DEPENDENT SODIUM CHANNELS
- MODULATION OF AMYLOID PRECURSOR PROTEIN METABOLISM BY X11ALPHA/MINT-1
- MODULATION OF APP METABOLISM BY X11ALPHA/MINT-1