Selected Publications article Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans.. Neurobiology of aging. 102-112. 2024 Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.. Neurobiology of aging. 46-54. 2024 Plasma proteomic profile of abdominal obesity in older adults.. Obesity (Silver Spring, Md.). 32:938-948. 2024 Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.. medRxiv : the preprint server for health sciences. 2023 Organ aging signatures in the plasma proteome track health and disease.. Nature. 624:164-172. 2023 Challenges in catalyzing and sustaining research in translational science.. Journal of clinical and translational science. 7:-. 2023 Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival.. The journals of gerontology. Series A, Biological sciences and medical sciences. 78:1771-1777. 2023 Discovering Biological Mechanisms of Exceptional Human Health Span and Life Span.. Cold Spring Harbor perspectives in medicine. 13. 2023 SuperAger Initiative: unlocking the genetic potential of exceptional longevity.. Nature aging. 3:627-628. 2023 Biological Age Acceleration and Motoric Cognitive Risk Syndrome.. Annals of neurology. 93:1187-1197. 2023 Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:2265-2275. 2022 Age-related changes in gait domains: Results from the LonGenity study.. Gait & posture. 8-13. 2022 Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey.. Cerebral circulation - cognition and behavior. -. 2022 Looking at IGF-1 through the hourglass.. Aging. 14:6379-6380. 2022 A metabolomic signature of the APOE2 allele.. GeroScience. 45:415-426. 2022 Integrity of hypothalamic-pituitary-testicular axis in exceptional longevity.. Aging cell. 21:-. 2022 Relative Trajectories of Gait and Cognitive Decline in Aging.. The journals of gerontology. Series A, Biological sciences and medical sciences. 77:1230-1238. 2022 Rare genetic coding variants associated with human longevity and protection against age-related diseases.. Nature aging. 1:783-794. 2021 Extending human healthspan and longevity: a symposium report.. Annals of the New York Academy of Sciences. 1507:70-83. 2021 Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span.. GeroScience. 43:2167-2182. 2021 The antagonistic pleiotropy of insulin-like growth factor 1.. Aging cell. 20:-. 2021 Trajectories of frailty in aging: Prospective cohort study.. PloS one. 16:-. 2021 A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations.. Frontiers in genetics. -. 2021 Common diseases alter the physiological age-related blood microRNA profile.. Nature communications. 11:-. 2020 Plasma proteomic profile of age, health span, and all-cause mortality in older adults.. Aging cell. 19:-. 2020 Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.. Aging cell. 19:-. 2020 Plasma proteomic profile of frailty.. Aging cell. 19:-. 2020 Genetics of extreme human longevity to guide drug discovery for healthy ageing.. Nature metabolism. 2:663-672. 2020 Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults.. Cells. 9. 2020 Undulating changes in human plasma proteome profiles across the lifespan.. Nature medicine. 25:1843-1850. 2019 Frailty and Risk of Incident Motoric Cognitive Risk Syndrome.. Journal of Alzheimer's disease : JAD. 71:S85-S93. 2019 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain.. Journal of molecular endocrinology. 61:T171-T185. 2018 Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty.. Frontiers in medicine. -. 2018 Association between Sleep Patterns and Health in Families with Exceptional Longevity.. Frontiers in medicine. -. 2017 The role of dietary patterns and exceptional parental longevity in healthy aging.. Nutrition and healthy aging. 4:247-254. 2017 Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging.. The journals of gerontology. Series A, Biological sciences and medical sciences. 72:1649-1655. 2017 Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring.. The American journal of cardiology. 120:2170-2175. 2017 Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population.. Neurobiology of aging. 238.e1-238.e8. 2017 Symptoms of Apathy Independently Predict Incident Frailty and Disability in Community-Dwelling Older Adults.. The Journal of clinical psychiatry. 78:e529-e536. 2017 Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function.. Aging. 8:2414-2424. 2016 Strategies and Challenges in Clinical Trials Targeting Human Aging.. The journals of gerontology. Series A, Biological sciences and medical sciences. 71:1424-1434. 2016 Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity.. Journal of the American Geriatrics Society. 64:1583-91. 2016 The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research.. Cell metabolism. 23:980-989. 2016 Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.. Cold Spring Harbor perspectives in medicine. 6:-. 2015 The influence of gender on inheritance of exceptional longevity.. Aging. 7:412-8. 2015 MEDULLARY THYROID CANCER THAT STAINS NEGATIVE FOR CA 19-9 HAS DECREASED METASTATIC POTENTIAL.. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 21:590-4. 2015 Association of exceptional parental longevity and physical function in aging.. Age (Dordrecht, Netherlands). 36:-. 2014 GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence.. Diabetologia. 57:1623-34. 2014 Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.. Aging cell. 13:769-71. 2014 Individuals with exceptional longevity manifest a delayed association between vitamin D insufficiency and cognitive impairment.. Journal of the American Geriatrics Society. 62:153-8. 2014 Phenotypes and genotypes of high density lipoprotein cholesterol in exceptional longevity.. Current vascular pharmacology. 12:690-7. 2014 Opioid receptor blockade prevents exercise-associated autonomic failure in humans.. Diabetes. 61:1609-15. 2012 Magnitude of exercise-induced β-endorphin response is associated with subsequent development of altered hypoglycemia counterregulation.. The Journal of clinical endocrinology and metabolism. 97:623-31. 2011 Opioid receptor blockade improves hypoglycemia-associated autonomic failure in type 1 diabetes mellitus.. The Journal of clinical endocrinology and metabolism. 96:3424-31. 2011 Metastatic medullary thyroid cancer presenting with elevated levels of CA 19-9 and CA 125.. Thyroid : official journal of the American Thyroid Association. 21:913-6. 2011 Mechanisms of vascular complications in prediabetes.. The Medical clinics of North America. 95:309-25, vii. 2011 Proton pump inhibitor-induced hypocalcemic seizure in a patient with hypoparathyroidism.. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 17:104-7. 2011
Principal Investigator on CH in Aging and Exceptional Longevity 2024 - 2029 Development of a Growth Hormone Receptor antagonist for the delay or prevention of ADRD 2024 - 2026 Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging 2010 - 2025 Somatotropic Signaling and Resilience to Aging and Alzheimer's Disease 2019 - 2025 Cognitive and Emotional Resilience to the COVID-19 pandemic among older adults at risk for Alzheimer's disease 2019 - 2024 Multi-omics approach to frailty resilience 2021 - 2023 Effect of longevity genomes on the GH/IGF-1 phenotype and disease-free survival 2015 - 2022
Available to Provide Advice to Those At different institutions (mentor and mentee are at different institutions) At my institution (mentor and mentee at same institution but different research interests or departments) From different disciplines or subspecialties
Available to be Contacted for Career (e.g. networking, how to get grants, how to publish, how to get tenure, how to start a geriatric specialty clinic) Research (e.g. reviewing study design, specific aims, selecting instruments) Work/Life Balance (e.g. counseling on job stress, dual-career households, self-care)
Interest in Transdisciplinary Projects Yes, but I do not have a specific project in mind yet (theoretical interest)