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Judith E. Carroll, PhD
Positions
- Associate Professor, University of California, Los Angeles
At the core of my research interests is understanding what contributes to vulnerability and resilience in aging at the biological level. I am particularly interested in what behavioral and psychosocial factors may act as a modifier of aging in various contexts. One area of active investigation is examining the role of cancer treatments in aging trajectories, the role of aging biology in the etiology of the late effects of cancer treatment (e.g, frailty and cognitive decline), and the interactive relationship with behavioral factors such as chronic stress, anxiety, discrimination, sleep disturbances and depression.
Clinical Disciplines
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Affiliation
Publications
Selected Publications
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article
- Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.. Journal of cancer survivorship : research and practice. 2023
- Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study.. Cancer. 129:2741-2753. 2023
- Plasma levels of interleukin-6 mediate neurocognitive performance in older breast cancer survivors: The Thinking and Living With Cancer study.. Cancer. 129:2409-2421. 2023
- Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 41:295-306. 2022
- Associating persistent self-reported cognitive decline with neurocognitive decline in older breast cancer survivors using machine learning: The Thinking and Living with Cancer study.. Journal of geriatric oncology. 13:1132-1140. 2022
- Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study.. Proceedings of the National Academy of Sciences of the United States of America. 119:-. 2022
- Stress-induced biological aging: A review and guide for research priorities.. Brain, behavior, and immunity. 97-109. 2022
- Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults.. Clinical epigenetics. 14:-. 2022
- Association of markers of tumor aggressivity and cognition in women with breast cancer before adjuvant treatment: The Thinking and Living with Cancer Study.. Breast cancer research and treatment. 194:413-422. 2022
- Multimodal MRI examination of structural and functional brain changes in older women with breast cancer in the first year of antiestrogen hormonal therapy.. Breast cancer research and treatment. 194:113-126. 2022
- Chronic stress increases transcriptomic indicators of biological aging in mouse bone marrow leukocytes.. Brain, behavior, & immunity - health. -. 2022
- Associations between longitudinal changes in sleep disturbance and depressive and anxiety symptoms during the COVID-19 virus pandemic among older women with and without breast cancer in the thinking and living with breast cancer study.. Cancer medicine. 11:3352-3363. 2022
- Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and Retirement Study.. SSM - population health. -. 2022
- Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care.. Nature reviews. Clinical oncology. 19:173-187. 2021
- Impact of taxane-based chemotherapy among older women with breast cancer on cognition and quality of life: a longitudinal pooled analysis.. Breast cancer research and treatment. 191:459-469. 2021
- Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations.. JAMA oncology. 7:1692-1699. 2021
- Response to Dekker, Stege, and Versteeg.. Journal of the National Cancer Institute. 113:1436-1437. 2021
- Sleep Disruption, Fatigue, and Depression as Predictors of 6-Year Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation.. Journal of the National Cancer Institute. 113:1405-1414. 2021
- Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors.. Breast cancer research and treatment. 190:287-293. 2021
- Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time.. NPJ breast cancer. 7:-. 2021
- Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation.. Brain, behavior, & immunity - health. 2021
- Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study.. Journal of the National Cancer Institute. 113:1053-1064. 2021
- Associations between sleep duration, shift work, and infectious illness in the United States: Data from the National Health Interview Survey.. Sleep health. 7:638-643. 2021
- Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls.. Cancer. 127:3671-3679. 2021
- Measuring Biologic Resilience in Older Cancer Survivors.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39:2079-2089. 2021
- Postpartum sleep loss and accelerated epigenetic aging.. Sleep health. 7:362-367. 2021
- Sleep and endocrine therapy in breast cancer.. Current opinion in endocrine and metabolic research. 165-170. 2021
- Sleep and Biological Aging: A Short Review.. Current opinion in endocrine and metabolic research. 159-164. 2021
- APOE. JNCI cancer spectrum. 5. 2021
- Insomnia and Susceptibility to Depressive Symptoms and Fatigue in Diverse Breast Cancer Survivors.. Journal of women's health (2002). 30:1604-1615. 2020
- Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length.. Psychoneuroendocrinology. -. 2020
- Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight.. Clinical epigenetics. 12:-. 2020
- The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.. NPJ breast cancer. -. 2020
- Sleep disturbances and inflammatory gene expression among pregnant women: Differential responses by race.. Brain, behavior, and immunity. 654-660. 2020
- Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women's Health Initiative (WHI).. The Journal of clinical endocrinology and metabolism. 105:1221-7. 2020
- Psychosocial Stressors and Telomere Length: A Current Review of the Science.. Annual review of public health. 223-245. 2020
- Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study.. Cancer. 126:1183-1192. 2019
- Pro-inflammatory immune cell gene expression during the third trimester of pregnancy is associated with shorter gestational length and lower birthweight.. American journal of reproductive immunology (New York, N.Y. : 1989). 82:-. 2019
- Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype.. Cancer. 125:4516-4524. 2019
- Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis.. Sleep. 42. 2019
- Sleep quality across pregnancy and postpartum: effects of parity and race.. Sleep health. 5:327-334. 2019
- Acute psychological stress increases serum circulating cell-free mitochondrial DNA.. Psychoneuroendocrinology. 268-276. 2019
- Maternal Sleep in Pregnancy and Postpartum Part I: Mental, Physical, and Interpersonal Consequences.. Current psychiatry reports. 21:-. 2019
- Maternal Sleep in Pregnancy and Postpartum Part II: Biomechanisms and Intervention Strategies.. Current psychiatry reports. 21:-. 2019
- Tracking geometric and hemodynamic alterations of an arteriovenous fistula through patient-specific modelling.. Computer methods and programs in biomedicine. -. 2019
- Sociodemographic correlates of change in leukocyte telomere length during mid- to late-life: The Multi-Ethnic Study of Atherosclerosis.. Psychoneuroendocrinology. 182-188. 2018
- Cognitive performance in survivors of breast cancer and markers of biological aging.. Cancer. 125:298-306. 2018
- Pretreatment Psychoneurological Symptoms and Their Association With Longitudinal Cognitive Function and Quality of Life in Older Breast Cancer Survivors.. Journal of pain and symptom management. 57:596-606. 2018
- Elevated pro-inflammatory gene expression in the third trimester of pregnancy in mothers who experienced stressful life events.. Brain, behavior, and immunity. 97-103. 2018
- Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 36:-. 2018
- Screening for childhood adversity: the what and when of identifying individuals at risk for lifespan health disparities.. Journal of behavioral medicine. 41:516-527. 2018
- Biomarkers of aging associated with past treatments in breast cancer survivors.. NPJ breast cancer. -. 2017
- Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length.. Frontiers in aging neuroscience. -. 2017
- Abnormal levels of vascular endothelial biomarkers in schizophrenia.. European archives of psychiatry and clinical neuroscience. 268:849-860. 2017
- Alzheimer's Disease Caregivers' Health and Important Resources: Next Steps in Intervention Research.. Psychosomatic medicine. 79:732-734. 2017
- Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability.. Sleep. 40. 2017
- Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study.. Sleep medicine. 72-79. 2016
- Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study.. Biological psychiatry. 81:136-144. 2016
- Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health.. Sleep. 39:727-36. 2016
- Insomnia and Telomere Length in Older Adults.. Sleep. 39:559-64. 2016
- Emotions and family interactions in childhood: Associations with leukocyte telomere length emotions, family interactions, and telomere length.. Psychoneuroendocrinology. 343-50. 2015
- Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.. Brain, behavior, and immunity. 223-229. 2015
- Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.. Biological psychiatry. 80:40-52. 2015
- Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial.. Psychoneuroendocrinology. 184-92. 2015
- Sleep and multisystem biological risk: a population-based study.. PloS one. 10:-. 2015
- Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging.. Sleep. 38:205-11. 2015
- Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial.. Sleep. 37:1543-52. 2014
- Neighborhood characteristics and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis.. Health & place. 167-72. 2014
- Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study.. Proceedings of the National Academy of Sciences of the United States of America. 110:17149-53. 2013
- Low social support is associated with shorter leukocyte telomere length in late life: multi-ethnic study of atherosclerosis.. Psychosomatic medicine. 75:171-7. 2013
- Socioeconomic factors and leukocyte telomere length in a multi-ethnic sample: findings from the multi-ethnic study of atherosclerosis (MESA).. Brain, behavior, and immunity. 108-14. 2012
- Restorative biological processes and health.. Social and personality psychology compass. 5:518-537. 2011
- Early childhood socioeconomic status is associated with circulating interleukin-6 among mid-life adults.. Brain, behavior, and immunity. 25:1468-74. 2011
- Negative affective responses to a speech task predict changes in interleukin (IL)-6.. Brain, behavior, and immunity. 25:232-8. 2010
- A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteers.. Psychosomatic medicine. 72:273-80. 2010
- Gender differences in stimulated cytokine production following acute psychological stress.. Brain, behavior, and immunity. 23:622-8. 2008
- Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes.. Journal of neuroimmunology. 167:34-44. 2005
Research
Principal Investigator on
- Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias 2023 - 2028
- Accelerated biological aging in breast cancer and risk for cognitive and physical complaints 2020 - 2024
- I-REACH: Infrastructure for Research in Equity, Aging, Cancer and Health 2022 - 2024
- Heterogeneity in biological, physical, and cognitive aging in older breast cancer survivors and controls 2021 - 2023
- A Randomized Trial for Sleep Disturbances to Reverse Cellular Aging 2016 - 2022
- Late life sleep disturbances: Effects on cell stress, telomerase, inflammation 2013 - 2018
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Interest in Transdisciplinary Projects
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Areas of Focus
- Geroscience
- Biobehavioral mechanisms
- Health equity and disparities