Publications in VIVO

Co-author Network

Co-investigator Network

Charles Mobbs

Professor

Positions

Professor, Icahn School of Medicine at Mount Sinai
Professor, Icahn School of Medicine at Mount Sinai 1992 -

Location

New York, NY 10029

United States

Clinical Disciplines

Publications
Research
Teaching
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Background
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Selected Publications

article
1. Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT. Neurobiology of Disease. 2016
2. Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports. 2015
3. Laparotomy in mice induces blood cell expression of inflammatory and stress genes. Journal of Interferon and Cytokine Research. 2015
4. Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports. 2015
5. Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types. Proteomics. 2013
6. Glucose-induced metabolic memory in Schwann cells: Prevention by PPAR agonists. Endocrinology. 2013
7. Hypothalamic EphA5 facilitates counterregulatory responses: Possible role for bidirectional signaling leading to bistability that enhances responsiveness to hypoglycemia. Diabetes. 2013
8. Metabolic mystery: Aging, obesity, diabetes, and the ventromedial hypothalamus. Trends in Endocrinology and Metabolism. 2013
9. Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain. Endocrinology and Metabolism Clinics of North America. 2013
10. Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Frontiers in Neuroendocrinology. 2013
11. Treatment of diabetes and diabetic complications with a ketogenic diet. Journal of Child Neurology. 2013
12. Hypothalamic BDNF and obesity: Found in translation. Nature Medicine. 2012
13. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. American Journal of Physiology - Endocrinology and Metabolism. 2012
14. Neuroprotection by dietary restriction and the PPAR transcription complex. Translational Neuroscience. 2012
15. Erratum: Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity (Nature Medicine (2011) 17 (1121-1127)). Nature Medicine. 2011
16. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on Cbp and protect against proteotoxicity. PLoS ONE. 2011
17. Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice. Nutrition and Diabetes. 2011
18. Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia: Role of metabolic reprogramming in counterregulatory failure. Diabetes. 2011
19. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine. 2011
20. Reversal of diabetic nephropathy by a ketogenic diet. PLoS ONE. 2011
21. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age. 2010
22. Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation. Endocrinology. 2010
23. Estradiol impairs hypothalamic molecular responses to hypoglycemia. Brain Research. 2009
24. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biology. 2009
25. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mechanisms of Ageing and Development. 2009
26. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Experimental Gerontology. 2008
27. Inhibition of Agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology. 2008
28. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Experimental Gerontology. 2008
29. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine. 2007
30. Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression. Endocrinology. 2007
31. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: A metabolic mechanism resolving the paradox. Appetite. 2007
32. Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2007
33. The "Domino Theory" of Hunger: The Hypothalamus Is Hot. Cell Metabolism. 2007
34. Fathead: The gain in brain falls mainly wit leptin wane. Endocrinology. 2006
35. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes. 2005
36. Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance-associated promotion of Alzheimer's disease β-amyloid neuropathology. FASEB Journal. 2005
37. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: The glucoadipostatic hypothesis. Physiology and Behavior. 2005
38. VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology. 2005
39. Daily nasal inoculation with the insulin gene ameliorates diabetes in mice. Diabetes Research and Clinical Practice. 2004
40. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004
41. Lifespan is not determined by metabolic rate: Evidence from fishes and C. elegans. Experimental Gerontology. 2004
42. Lobotomy of genes: Use of RNA interference in neuroscience. Neuroscience. 2004
43. Metabolic Pathways that Mediate Inhibition of Hypothalamic Neurons by Glucose. Diabetes. 2004
44. Mining microarrays for metabolic meaning: Nutritional regulation of hypothalamic gene expression. Neurochemical Research. 2004
45. Not wisely but too well: aging as a cost of neuroendocrine activity.. Science of aging knowledge environment : SAGE KE. 2004
46. Obesity over the life course.. Science of aging knowledge environment : SAGE KE. 2004
47. Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain. Molecular and Cellular Neuroscience. 2004
48. Specific Preservation of Biosynthetic Responses to Insulin in Adipose Tissue May Contribute to Hyperleptinemia in Insulin-Resistant Obese Mice. Journal of Nutrition. 2004
49. Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity. BMC Physiology. 2003
50. Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity.. BMC physiology [electronic resource]. 2003
51. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes. 2003
52. D-chiro-Inositol enhances effects of hypothalamic toxin gold-thioglucose. Brain Research. 2003
53. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression.. BMC physiology [electronic resource]. 2003
54. The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons. Brain Research. 2003
55. The physiological function of the agouti-related peptide gene: The control of weight and metabolic rate. Annals of Medicine. 2003
56. Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice. Diabetes. 2003
57. Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA. American Journal of Physiology - Endocrinology and Metabolism. 2002
58. Block the FAS, lose the fat. Nature Medicine. 2002
59. Reducing hypothalmic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neuroscience. 2002
60. VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. Journal of Neuroscience. 2002
61. Validated genomic approach to study differentially expressed genes in complex tissues. Neurochemical Research. 2002
62. Brain glucose-sensing mechanisms: Ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. American Journal of Physiology - Endocrinology and Metabolism. 2001
63. Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes. 2001
64. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. The journals of gerontology. Series A, Biological sciences and medical sciences. 2001
65. Workshop on hypoglycemia and the brain. Diabetes Technology and Therapeutics. 2001
66. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Diabetes. 2000
67. Age-related changes in leptin: Consequences and mechanisms. Reviews in Clinical Gerontology. 2000
68. Changes in estrogenic regulation of estrogen receptor α mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: An in situ hybridization study. Neuroscience Research. 2000
69. Liposome mediated gene transfer into GH3 cells, and rat brain, liver and gut: comparison of different polar or aliphatic domains.. International journal of surgical investigation. 2000
70. T lymphopenia in genetically obese-diabetic Wistar fatty rats: Effects of body weight reduction on T cells. Metabolism: Clinical and Experimental. 2000
71. Effects of tumor necrosis factor alpha on leptin secretion and gene expression: Relationship to changes of glucose metabolism in isolated rat adipocytes. International Journal of Obesity. 1999
72. Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology. 1999
73. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology. 1999
74. Hypothalamic glucose sensor: Similarities to and differences from pancreatic β-cell mechanisms. Diabetes. 1999
75. Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Research. 1999
76. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron. 1999
77. Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats. Mechanisms of Ageing and Development. 1998
78. Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: An in situ hybridization histochemistry study. General and Comparative Endocrinology. 1998
79. Erratum: Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin (Diabetes (1998) 47 (294-297)). Diabetes. 1998
80. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology. 1998
81. Hyperphagia and weight gain after gold-thioglucose: Relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology. 1998
82. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes. 1998
83. Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Hormone and Metabolic Research. 1997
84. Widespread expression and estrogen regulation of PPEIA-3′ nuclear RNA in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. 1997
85. Effects of nutritional status and aging on leptin gene expression in mice: Importance of glucose. Hormone and Metabolic Research. 1996
86. Injection with gold thioglucose impairs sensitivity to glucose: Evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Research. 1996
87. Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proceedings of the National Academy of Sciences of the United States of America. 1996
88. Plasma leptin is directly related to body adiposity in subjects with spinal cord injury. Hormone and Metabolic Research. 1996
89. Ventromedial hypothalamic lesions produced by gold thioglucose do not impair induction of NPY mRNA in the arcuate nucleus by fasting. Brain Research. 1996
90. Changes in preproenkephalin messenger RNA level in the rat ventromedial hypothalamus during the estrous cycle. Molecular Brain Research. 1995
91. Infusion of antisense oligodeoxynucleotides to the oxytocin receptor in the ventromedial hypothalamus reduces estrogen- induced sexual receptivity and oxytocin receptor binding in the female rat. Neuroendocrinology. 1994
92. Molecular hysteresis: Residual effects of hormones and glucose on genes during aging. Neurobiology of Aging. 1994
93. Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proceedings of the National Academy of Sciences of the United States of America. 1994
94. Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: A review. Neuroscience and Biobehavioral Reviews. 1994
95. Cell-specific expression of preproenkephalin intronic heteronuclear RNA in the rat forebrain. Molecular Brain Research. 1993
96. DNA methylation and DNase-hypersensitive sites in the 5' flanking and transcribed regions of the rat preproenkephalin gene: Studies of mediobasal hypothalamus. Molecular and Cellular Neurosciences. 1993
97. Detection of messenger RNA and low-abundance heteronuclear RNA with single-stranded DNA probes produced by amplified primer extension labeling. Journal of Histochemistry and Cytochemistry. 1993
98. Estrogen increases HIP-70/PLC-α messenger ribonucleic acid in the rat uterus and hypothalamus. Endocrinology. 1993
99. Genetic influences on glucose neurotoxicity, aging, and diabetes: A possible role for glucose hysteresis. Genetica. 1993
100. Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain. Brain Research. 1993
101. Estrogen-induced impairments as a mechanism in reproductive senescence of female C57BL/6J mice. Journals of Gerontology. 1992
102. Estrogenic regulation of heat shock protein 90 kDa in the rat ventromedial hypothalamus and uterus. Molecular and Cellular Endocrinology. 1992
103. Gene memory in neuroendocrine and behavioural systems.. Ciba Foundation symposium. 1992
104. Prolactin receptor messenger RNA is synthesized by the epithelial cells of the choroid plexus. Molecular Brain Research. 1992
105. Sex differences in the regulation of heat shock protein 70 kDa and 90 kDa in the rat ventromedial hypothalamus by estrogen. Brain Research. 1992
106. Estrogen receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose. Endocrinology. 1991
107. PLC-α: A common mediator of the action of estrogen and other hormones?. Molecular and Cellular Endocrinology. 1991
108. Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: implications for the molecular basis of a sexually differentiated behavior. Brain Research. 1990
109. Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat. Molecular Brain Research. 1990
110. Estradiol regulation of estrogen receptor messenger ribonucleic acid in rat mediobasal hypothalamus: An in situ hybridzation study. Journal of Neuroendocrinology. 1990
111. HIP-70: A protein induced by estrogen in the brain and LH-RH in the pituitary. Science. 1990
112. HIP-70: An isoform of phosphoinositol-specific phospholipase C-α. I. Science. 1990
113. Sex steroids and fos expression in rat brain and uterus. Molecular and Cellular Neuroscience. 1990
114. Comprehensive polypeptide analysis of microdissected rat brain areas: combining 2-dimensional gel electrophoresis with 2-dimensional HPLC and immunoanalysis and sequencing procedures. Journal of Neuroscience Methods. 1989
115. Considerations in the quantitative analysis of autoradiograms from 2-dimensional gels. Journal of Neuroscience Methods. 1989
116. Differential effects of estradiol and 16α-hydroxyestrone on pituitary and preoptic estrogen receptor regulation. Endocrinology. 1989
117. Estrogen regulation of proenkephalin gene expression in the ventromedial hypothalamus of the rat: temporal qualities and synergism with progesterone. Molecular Brain Research. 1989
118. Phorbol esters and forskolin infused into midbrain central gray facilitate lordosis. Pharmacology Biochemistry and Behavior. 1989
119. Similarity of an estrogen-induced protein and a luteinizing hormone releasing hormone-induced protein. Molecular and Cellular Endocrinology. 1989
120. Temporal actions of 16α-hydroxyestrone in the rat: Comparisons of lordosis dynamics with other estrogen metabolites and between sexes. Journal of Steroid Biochemistry. 1989
121. Two-dimensional gel autoradiographic analysis of the acute effects of estradiol on protein synthesis in the female rat ventromedial nucleus in vivo. Endocrinology. 1989
122. Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice. Experimental Gerontology. 1988
123. An estradiol-induced protein synthesized in the ventral medial hypothalamus and transported to the midbrain central gray. Journal of Neuroscience. 1988
124. Pituitary and hypothalamic glucose-6-phosphate dehydrogenase: Effects of estradiol and age in C57BL/6J mice. Endocrinology. 1988
125. The increase of anterior pituitary dopamine in aging C57BL/6J female mice is caused by ovarian steroids, not intrinsic pituitary aging. Neuroendocrinology. 1986
126. Age-correlated and ovary-dependent changes in relationships between plasma estradiol and luteinizing hormone, prolactin, and growth hormone in female C57BL/6J mice. Endocrinology. 1985
127. Delayed anovulatory syndrome induced by estradiol in female C57BL/6J mice: Age-like neuroendocrine, but not ovarian, impairments. Biology of Reproduction. 1985
128. The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh. Neuroendocrinology. 1985
129. Estradiol-induced adult anovulatory syndrome in female C57BL/6J mice: Age-like neuroendocrine, but not ovarian, impairments. Biology of Reproduction. 1984
130. Hyperprolactinemia fails to increase striatal dopamine receptors in male and female C57BL/6J mice. European Journal of Pharmacology. 1984
131. Ovarian and steroidal influences on neuroendocrine aging processes in female rodents.. Endocrine Reviews. 1984
132. Reproductive senescence in female C57BL/6J mice: Ovarian impairments and neuroendocrine impairments that are partially reversible and delayable by ovariectomy. Endocrinology. 1984
133. The regulation of luteinizing hormone and prolactin in C57BL/6J mice: Effects of estradiol implant size, duration of ovariectomy, and aging. Endocrinology. 1984
134. Studies on ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice. Peptides. 1980
document
1. Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study 2024
2. Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis 2023
3. Body composition and aging. Body Composition and Aging. 2010
4. Interdisciplinary Topics in Gerontology: Preface. Interdisciplinary Topics in Gerontology. 2010
5. Oxidative Stress and Acidosis, Molecular Responses to. Encyclopedia of Stress. 2010
6. Oxidative Stress and Aging. Encyclopedia of Stress. 2010
7. Preface. Body Composition and Aging. 2010
8. Interdisciplinary Topics in Gerontology: Preface. Interdisciplinary Topics in Gerontology. 2007
9. Secrets of the lac operon. Interdisciplinary Topics in Gerontology. 2007
10. Leptin regulation of proopiomelanocortin. Frontiers of Hormone Research. 1999
11. Estradiol-Regulated Neuronal Plasticity. Current Topics in Membranes and Transport. 1987