Selected Publications
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article
- Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease.. Science advances. 10:-. 2024
- Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy.. Animals : an open access journal from MDPI. 14. 2024
- GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.. JCI insight. 8. 2023
- Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1.. The Journal of nutrition. 153:3397-3405. 2023
- Postabsorptive muscle protein synthesis is higher in outpatients as compared to inpatients.. American journal of physiology. Endocrinology and metabolism. 325:E113-E118. 2023
- The transcription regulator ATF4 is a mediator of skeletal muscle aging.. GeroScience. 45:2525-2543. 2023
- Skeletal Muscle Bioenergetics in Critical Limb Ischemia and Diabetes.. The Journal of surgical research. 108-117. 2023
- Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice.. Journal of ageing and longevity. 3:159-178. 2022
- Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.. The Journal of nutrition. 152:926-938. 2022
- Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle.. Nutrition & metabolism. 18:-. 2021
- Measuring Exercise Capacity and Physical Function in Adult and Older Mice.. The journals of gerontology. Series A, Biological sciences and medical sciences. 76:819-824. 2021
- Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.. Journal of applied physiology (Bethesda, Md. : 1985). 128:795-804. 2020
- Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.. Experimental gerontology. -. 2019
- Whey Protein Hydrolysate Increases Amino Acid Uptake, mTORC1 Signaling, and Protein Synthesis in Skeletal Muscle of Healthy Young Men in a Randomized Crossover Trial.. The Journal of nutrition. 149:1149-1158. 2019
- Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial.. Clinical nutrition (Edinburgh, Scotland). 39:1371-1378. 2019
- The Importance of Resistance Exercise Training to Combat Neuromuscular Aging.. Physiology (Bethesda, Md.). 34:112-122. 2019
- Moderate-intensity aerobic exercise improves skeletal muscle quality in older adults.. Translational sports medicine. 2:109-119. 2019
- Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.. The Journal of biological chemistry. 294:4091-4102. 2019
- Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia.. Experimental gerontology. 88-100. 2018
- Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training.. Medicine and science in sports and exercise. 49:1197-1208. 2017
- Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.. Nutrition & metabolism. -. 2017
- Post-absorptive muscle protein turnover affects resistance training hypertrophy.. European journal of applied physiology. 117:853-866. 2017
- Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men.. The Journal of nutrition. 146:2468-2475. 2016
- The impact of postexercise essential amino acid ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men.. Journal of applied physiology (Bethesda, Md. : 1985). 122:620-630. 2016
- Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function.. Cell metabolism. 24:246-55. 2016
- Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial.. The Journal of nutrition. 146:1660-9. 2016
- Amino Acid Sensing in Skeletal Muscle.. Trends in endocrinology and metabolism: TEM. 27:796-806. 2016
- Increasing Insulin Availability Does Not Augment Postprandial Muscle Protein Synthesis Rates in Healthy Young and Older Men.. The Journal of clinical endocrinology and metabolism. 101:3978-3988. 2016
- Satellite cell activation and apoptosis in skeletal muscle from severely burned children.. The Journal of physiology. 594:5223-36. 2016
- Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.. American journal of physiology. Endocrinology and metabolism. 311:E436-48. 2016
- Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.. The Journal of nutrition. 146:155-83. 2016
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).. Autophagy. 12:1-222. 2016
- Long-Term Skeletal Muscle Mitochondrial Dysfunction is Associated with Hypermetabolism in Severely Burned Children.. Journal of burn care & research : official publication of the American Burn Association. 37:53-63. 2016
- Post-Prandial Protein Handling: You Are What You Just Ate.. PloS one. 10:-. 2015
- Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle.. Medicine and science in sports and exercise. 47:1922-31. 2015
- Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle.. American journal of physiology. Endocrinology and metabolism. 309:E224-32. 2015
- Defining meal requirements for protein to optimize metabolic roles of amino acids.. The American journal of clinical nutrition. 101:1330S-1338S. 2015
- Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle.. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 40:788-796. 2015
- Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women.. Experimental gerontology. 1-7. 2015
- Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury.. European journal of applied physiology. 115:111-8. 2014
- Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men.. The Journal of nutrition. 144:1694-702. 2014
- Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults.. American journal of physiology. Endocrinology and metabolism. 307:E462-7. 2014
- Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle.. Journal of applied physiology (Bethesda, Md. : 1985). 116:1353-64. 2014
- Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin.. American journal of physiology. Endocrinology and metabolism. 306:E1198-204. 2014
- Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells.. Physiological reports. 2:-. 2014
- Amino acid transporters in the regulation of human skeletal muscle protein metabolism.. Current opinion in clinical nutrition and metabolic care. 16:638-44. 2013
- Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle.. Exercise and sport sciences reviews. 41:216-23. 2013
- Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage.. PloS one. 8:-. 2013
- Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults.. American journal of physiology. Regulatory, integrative and comparative physiology. 305:R216-23. 2013
- Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism.. The Journal of nutrition. 143:307-14. 2013
- Protein blend ingestion following resistance exercise promotes human muscle protein synthesis.. The Journal of nutrition. 143:410-6. 2013
- Paraplegia increases skeletal muscle autophagy.. Muscle & nerve. 46:793-8. 2012
- Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults.. The journals of gerontology. Series A, Biological sciences and medical sciences. 68:599-607. 2012
- A soy, whey and caseinate blend extends postprandial skeletal muscle protein synthesis in rats.. Clinical nutrition (Edinburgh, Scotland). 32:585-91. 2012
- Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle.. Metabolism: clinical and experimental. 62:144-51. 2012
- Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise.. Clinical nutrition (Edinburgh, Scotland). 32:273-80. 2012
- PAX7+ satellite cells in young and older adults following resistance exercise.. Muscle & nerve. 46:51-9. 2012
- A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults.. The American journal of clinical nutrition. 95:1403-12. 2012
- Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise.. Journal of applied physiology (Bethesda, Md. : 1985). 112:1520-8. 2012
- Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.. American journal of physiology. Endocrinology and metabolism. 302:E1113-22. 2012
- Exercise, amino acids, and aging in the control of human muscle protein synthesis.. Medicine and science in sports and exercise. 43:2249-58. 2011
- Skeletal muscle protein balance and metabolism in the elderly.. Current aging science. 4:260-8. 2011
- Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.. Journal of applied physiology (Bethesda, Md. : 1985). 111:135-42. 2011
- The missing Akt in the mechanical regulation of skeletal muscle mTORC1 signalling and growth.. The Journal of physiology. 589:-. 2011
- Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.. The Journal of nutrition. 141:856-62. 2011
- Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis.. Skeletal muscle. 1:-. 2011
- Does a reduction in anabolic signaling contribute to muscle wasting in chronic heart failure?. Journal of applied physiology (Bethesda, Md. : 1985). 110:869-70. 2011
- Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism.. Current opinion in clinical nutrition and metabolic care. 14:83-8. 2011
- Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis.. Physiological genomics. 43:595-603. 2010
- Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women.. The Journal of nutrition. 140:1970-6. 2010
- Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults.. Diabetes. 59:2764-71. 2010
- Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise.. American journal of physiology. Regulatory, integrative and comparative physiology. 299:R533-40. 2010
- Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling.. The Journal of clinical endocrinology and metabolism. 95:3848-57. 2010
- Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.. Journal of applied physiology (Bethesda, Md. : 1985). 108:1199-209. 2010
- An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle.. American journal of physiology. Endocrinology and metabolism. 298:E1011-8. 2010
- Resistance exercise increases leg muscle protein synthesis and mTOR signalling independent of sex.. Acta physiologica (Oxford, England). 199:71-81. 2010
- Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle.. The Journal of nutrition. 139:2279-84. 2009
- Phosphatidic acid: a novel mechanical mechanism for how resistance exercise activates mTORC1 signalling.. The Journal of physiology. 587:3415-6. 2009
- Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism.. Diabetologia. 52:1889-98. 2009
- Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis.. The Journal of physiology. 587:1535-46. 2009
- The balancing act between the cellular processes of protein synthesis and breakdown: exercise as a model to understand the molecular mechanisms regulating muscle mass.. Journal of applied physiology (Bethesda, Md. : 1985). 106:1365-6. 2009
- Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling.. Journal of applied physiology (Bethesda, Md. : 1985). 106:1374-84. 2009
- Dietary protein recommendations and the prevention of sarcopenia.. Current opinion in clinical nutrition and metabolic care. 12:86-90. 2009
- Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery.. Journal of applied physiology (Bethesda, Md. : 1985). 105:1967-74. 2008
- Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.. American journal of physiology. Endocrinology and metabolism. 295:E1333-40. 2008
- Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis.. Journal of applied physiology (Bethesda, Md. : 1985). 106:1403-11. 2008
- Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics.. American journal of physiology. Endocrinology and metabolism. 295:E959-63. 2008
- Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis.. Journal of applied physiology (Bethesda, Md. : 1985). 106:1730-9. 2008
- Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis.. Current opinion in clinical nutrition and metabolic care. 11:222-6. 2008
- Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle.. Muscle & nerve. 37:505-13. 2008
- Human muscle gene expression following resistance exercise and blood flow restriction.. Medicine and science in sports and exercise. 40:691-8. 2008
- Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle.. Clinical nutrition (Edinburgh, Scotland). 27:447-56. 2008
- Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.. Journal of applied physiology (Bethesda, Md. : 1985). 104:1452-61. 2008
- A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 33:93-101. 2008
- Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle.. American journal of physiology. Endocrinology and metabolism. 294:E392-400. 2007
- Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway.. Journal of applied physiology (Bethesda, Md. : 1985). 104:27-33. 2007
- Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis.. Journal of applied physiology (Bethesda, Md. : 1985). 103:903-10. 2007
- Nutrient signalling in the regulation of human muscle protein synthesis.. The Journal of physiology. 582:813-23. 2007
- Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling.. Diabetes. 56:1615-22. 2007
- Basal muscle intracellular amino acid kinetics in women and men.. American journal of physiology. Endocrinology and metabolism. 292:E77-83. 2006
- Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.. The Journal of physiology. 576:613-24. 2006
- Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.. Diabetologia. 49:2144-52. 2006
- Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability.. American journal of physiology. Endocrinology and metabolism. 291:E745-54. 2006
- Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes.. The Journal of nutrition. 136:1249-55. 2006
- Insulin resistance of muscle protein metabolism in aging.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20:768-9. 2006
- Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases.. American journal of physiology. Endocrinology and metabolism. 289:E999-1006. 2005
- The relationships between testosterone, body composition, and insulin resistance: a lesson from a case of extreme hyperandrogenism.. Diabetes care. 28:429-32. 2005
- Leg glucose and protein metabolism during an acute bout of resistance exercise in humans.. Journal of applied physiology (Bethesda, Md. : 1985). 97:1379-86. 2004
- Contractile and nutritional regulation of human muscle growth.. Exercise and sport sciences reviews. 31:127-31. 2003
- Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle.. The Journal of clinical investigation. 110:1687-93. 2002
- Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly.. The journal of nutrition, health & aging. 6:358-62. 2002
- Basal muscle amino acid kinetics and protein synthesis in healthy young and older men.. JAMA. 286:1206-12. 2001
- Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise.. American journal of physiology. Endocrinology and metabolism. 281:E197-206. 2001
- Alteration of hepatic fatty acid metabolism after burn injury in pigs.. JPEN. Journal of parenteral and enteral nutrition. 25:310-6. 2001
- The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.. The Journal of clinical endocrinology and metabolism. 85:4481-90. 2000
- Nutrition and muscle protein metabolism in the elderly.. Diabetes, nutrition & metabolism. 13:99-107. 2000
- An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise.. Journal of applied physiology (Bethesda, Md. : 1985). 88:386-92. 2000
- Androstenedione does not stimulate muscle protein anabolism in young healthy men.. The Journal of clinical endocrinology and metabolism. 85:55-9. 2000
- Regulation of fatty acid oxidation in skeletal muscle.. Annual review of nutrition. 463-84. 1999
- Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle.. Journal of applied physiology (Bethesda, Md. : 1985). 85:1909-14. 1998
- Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase.. Journal of applied physiology (Bethesda, Md. : 1985). 85:1629-34. 1998
- Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise.. Journal of applied physiology (Bethesda, Md. : 1985). 83:1917-22. 1997
- Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase.. Journal of applied physiology (Bethesda, Md. : 1985). 83:1104-9. 1997
- Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A.. Journal of applied physiology (Bethesda, Md. : 1985). 82:219-25. 1997