Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes.
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Overview
publication date
- January 2002
published in
- Arthritis and rheumatism Journal
has subject area
- Antibodies
- Cartilage, Articular
- Cell Adhesion
- Chondrocytes
- Collagenases
- Fibronectins
- Humans
- I-kappa B Proteins
- Integrin alpha2beta1
- Integrin alpha5beta1
- Integrins
- Matrix Metalloproteinase 13
- Mitogen-Activated Protein Kinases
- Peptide Fragments
- Phosphorylation
- Proto-Oncogene Proteins c-jun
- Signal Transduction