Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
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Overview
publication date
- January 1, 2003
published in
has subject area
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Aspartic Acid Endopeptidases
- CHO Cells
- Cricetinae
- Endopeptidases
- ErbB Receptors
- Humans
- In Vitro Techniques
- Membrane Proteins
- Peptide Fragments
- Protein Structure, Tertiary
- Receptor, ErbB-4
- Receptor, Notch1
- Receptors, Cell Surface
- Signal Transduction
- Transcription Factors
- Transcription, Genetic