The Journal of biological chemistry

publication venue for

Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy.. 299:-. 2023
Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.. 298:-. 2022
A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.. -. 2020
Caenorhabditis elegans. 294:9536-9554. 2019
Mass spectrometry-based molecular mapping of native FXIIIa cross-links in insoluble fibrin clots.. 294:8773-8778. 2019
Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.. 294:4091-4102. 2019
Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies.. 293:2408-2421. 2017
RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.. 293:1353-1362. 2017
Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.. 292:21643-21652. 2017
A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase.. 292:10639-10650. 2017
TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis.. 292:3420-3432. 2017
Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.. 291:26794-26805. 2016
Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.. 291:6641-54. 2016
The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).. 290:28847-56. 2015
Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.. 290:28097-28106. 2015
Amino Acid Availability Regulates the Effect of Hyperinsulinemia on Skin Protein Metabolism in Pigs.. 290:17776-17783. 2015
Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.. 290:15581-15594. 2015
Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.. 290:5267-79. 2015
Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.. 290:21652-62. 2015
Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis.. 290:19081-92. 2015
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis.. 289:24560-72. 2014
MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant.. 289:13434-44. 2014
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.. 289:3276-87. 2013
Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion.. 288:25088-25097. 2013
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.. 288:16937-16948. 2013
Signaling between transforming growth factor β (TGF-β) and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis.. 288:10241-53. 2013
The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.. 288:6814-25. 2013
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease.. 287:42436-43. 2012
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).. 287:40629-40. 2012
Identification of function for CD44 intracytoplasmic domain (CD44-ICD): modulation of matrix metalloproteinase 9 (MMP-9) transcription via novel promoter response element.. 287:18995-9007. 2012
Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach.. 287:14515-23. 2012
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.. 287:13959-71. 2012
Trans-cellular propagation of Tau aggregation by fibrillar species.. 287:19440-51. 2012
N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit.. 287:4348-59. 2011
Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes.. 286:35915-35921. 2011
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.. 286:39804-12. 2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.. 286:39794-803. 2011
Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease.. 286:33380-9. 2011
Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions.. 286:7490-5. 2011
Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.. 287:5412-25. 2011
Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13.. 285:31517-24. 2010
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.. 285:29569-76. 2010
Live cell fluorescence resonance energy transfer predicts an altered molecular association of heterologous PrPSc with PrPC.. 285:8967-75. 2010
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.. 284:31972-81. 2009
The pannexin 1 channel activates the inflammasome in neurons and astrocytes.. 284:18143-51. 2009
The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.. 284:17170-17179. 2009
Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.. 284:12246-57. 2009
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.. 284:2363-73. 2008
Identifying key components of the PrPC-PrPSc replicative interface.. 283:34021-8. 2008
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.. 283:17049-54. 2008
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.. 283:9127-35. 2008
Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats.. 283:13341-56. 2008
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.. 283:34554-62. 2008
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.. 282:32264-73. 2007
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.. 282:30150-60. 2007
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.. 282:26832-26844. 2007
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.. 282:20075-87. 2007
N-methyl-D-aspartate receptor-dependent regulation of the glutamate transporter excitatory amino acid carrier 1.. 282:17594-607. 2007
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.. 282:16441-53. 2007
Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.. 282:12310-8. 2007
Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes.. 282:11110-21. 2007
Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.. 281:16193-6. 2006
Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors.. 281:8476-85. 2006
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.. 281:36180-6. 2006
Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ.. 281:24566-74. 2006
Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.. 281:2730-9. 2005
N-methyl-D-aspartate receptor subtype mediated bidirectional control of p38 mitogen-activated protein kinase.. 280:29322-33. 2005
The AGAAAAGA palindrome in PrP is required to generate a productive PrPSc-PrPC complex that leads to prion propagation.. 280:27236-43. 2005
The E46K mutation in alpha-synuclein increases amyloid fibril formation.. 280:7800-7. 2005
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.. 280:43236-42. 2005
NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs.. 280:18981-9. 2005
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.. 280:25754-9. 2005
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.. 279:47746-53. 2004
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.. 279:43148-56. 2004
Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts.. 279:29121-9. 2004
Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products.. 279:29740-51. 2004
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.. 279:15153-60. 2004
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.. 279:40987-93. 2004
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.. 278:48529-33. 2003
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.. 278:48120-8. 2003
Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles.. 278:42976-84. 2003
Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.. 278:41798-803. 2003
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.. 278:31831-7. 2003
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.. 278:31825-30. 2003
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.. 278:30748-54. 2003
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.. 278:25386-94. 2003
Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.. 278:24577-85. 2003
37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake.. 278:16857-62. 2003
Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation.. 278:12894-902. 2003
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.. 278:13047-55. 2002
Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression.. 277:50137-42. 2002
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.. 277:26089-97. 2002
Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells.. 277:19374-81. 2002
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.. 277:36040-4. 2002
Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.. 278:8043-51. 2002
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.. 277:30128-36. 2002
Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion.. 276:38563-9. 2001
A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.. 276:481-7. 2001
The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines.. 275:28634-40. 2000
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.. 275:26277-84. 2000
Arcadlin is a neural activity-regulated cadherin involved in long term potentiation.. 274:19473-1979. 1999
gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length.. 274:11914-23. 1999
Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks.. 271:12165-71. 1996
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.. 271:4468-76. 1996
Mitochondrial voltage-dependent anion channel. Immunochemical and immunohistochemical characterization in rat brain.. 268:23289-96. 1993
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.. 267:17882-90. 1992
Cell adhesion to matrix Gla protein and its inhibition by an Arg-Gly-Asp-containing peptide.. 267:9459-62. 1992
Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.. 264:13896-901. 1989
The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins.. 244:440-8. 1969

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The Journal of biological chemistry Journal

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