Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.
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Overview
publication date
- January 1, 2003
published in
has subject area
- Blotting, Western
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins
- Cells, Cultured
- Chondrocytes
- Collagenases
- Culture Media, Conditioned
- DNA
- Dose-Response Relationship, Drug
- Down-Regulation
- Fibronectins
- Gene Deletion
- Humans
- Insulin-Like Growth Factor I
- Interleukin-1
- Luciferases
- Matrix Metalloproteinase 13
- Models, Genetic
- Plasmids
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- RNA
- RNA, Messenger
- Receptor, IGF Type 1
- Reverse Transcriptase Polymerase Chain Reaction
- Temperature
- Transfection
- Transforming Growth Factor beta
- Up-Regulation