A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
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Overview
publication date
- January 1, 2004
published in
has subject area
- Activating Transcription Factor 6
- Aspartic Acid Endopeptidases
- Binding Sites
- Biochemistry
- Blotting, Western
- Catalysis
- Catalytic Domain
- Cell Line
- Cell Membrane
- Cytoplasm
- DNA
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Genes, Reporter
- Glycosylation
- Humans
- Luciferases
- Membrane Proteins
- Mutagenesis, Site-Directed
- Presenilin-1
- Transcription Factors
- Transfection