Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.
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Overview
publication date
- January 1, 2009
published in
has subject area
- Ankle Joint
- Cartilage
- Cells, Cultured
- Chondrocytes
- Collagen Type II
- Enzyme-Linked Immunosorbent Assay
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Insulin-Like Growth Factor I
- Lentivirus
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Oxidative Stress
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Proteoglycans
- Proto-Oncogene Proteins c-akt
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction