Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
- Overview
- Identity
- Additional Document Info
- View All
Overview
publication date
- January 2009
published in
- Arthritis and rheumatism Journal
has subject area
- Adult
- Aged, 80 and over
- Ankle Joint
- Cartilage, Articular
- Cell Cycle Proteins
- Cell Survival
- Child
- Chondrocytes
- Enzyme Inhibitors
- Humans
- Insulin-Like Growth Factor I
- Middle Aged
- Osteoarthritis, Knee
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proteoglycans
- Proto-Oncogene Proteins c-akt
- Repressor Proteins
- Thapsigargin
- Tunicamycin
- Young Adult