Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
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Overview
publication date
- January 1, 2010
published in
- Neurobiology of disease Journal
has subject area
- Acetylcholinesterase
- Alternative Splicing
- Animals
- Cells, Cultured
- Cerebral Cortex
- Down Syndrome
- Dyrk Kinases
- Female
- Gene Dosage
- Gene Expression Regulation, Developmental
- Genetic Engineering
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- RNA Splicing