Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes.
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Overview
publication date
- January 1, 2012
published in
- Arthritis research & therapy Journal
has subject area
- Adipokines
- Butadienes
- Cartilage, Articular
- Cells, Cultured
- Chondrocytes
- Collagen Type II
- Enzyme Inhibitors
- Extracellular Signal-Regulated MAP Kinases
- Gene Expression
- Humans
- Immunoblotting
- Insulin Receptor Substrate Proteins
- Insulin-Like Growth Factor I
- MAP Kinase Signaling System
- Nicotinamide Phosphoribosyltransferase
- Nitriles
- Phosphorylation
- Proteoglycans
- Proto-Oncogene Proteins c-akt
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction