Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.
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Overview
publication date
- January 1, 2012
published in
has subject area
- Adaptor Proteins, Vesicular Transport
- Amino Acids
- Ammonium Chloride
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Antibodies, Monoclonal
- Aspartic Acid Endopeptidases
- Caspase 3
- Cell Death
- Cell Membrane
- Cells, Cultured
- Chloroquine
- Cycloheximide
- Dendritic Spines
- Disks Large Homolog 4 Protein
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Expression Regulation
- Hippocampus
- Humans
- Intracellular Signaling Peptides and Proteins
- Lysosomes
- Male
- Membrane Proteins
- Mice
- Neurons
- Neuropeptides
- Oligonucleotides
- Protein Synthesis Inhibitors
- Rats
- Transfection