The Journal of neuroscience : the official journal of the Society for Neuroscience

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ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.. 44. 2024
Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging.. 42:8587-8594. 2022
Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms.. 42:6593-6604. 2022
Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep.. 42:5007-5020. 2022
Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults.. 42:288-298. 2021
In Vivo. 41:8494-8507. 2021
4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.. 40:8734-8745. 2020
Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid.. 40:8573-8586. 2020
Longitudinal Basal Forebrain Degeneration Interacts with TREM2/C3 Biomarkers of Inflammation in Presymptomatic Alzheimer's Disease.. 40:1931-1942. 2020
Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction.. 39:8816-8825. 2019
Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress.. 39:1139-1149. 2018
Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.. 39:548-556. 2018
Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress.. 38:7505-7515. 2018
The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.. 38:2809-2817. 2018
Feedback-Based Learning in Aging: Contributions and Trajectories of Change in Striatal and Hippocampal Systems.. 38:8453-8462. 2018
Nonhuman Primate Optogenetics: Recent Advances and Future Directions.. 37:10894-10903. 2017
Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals.. 37:4323-4331. 2017
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.. 37:4023-4031. 2017
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.. 37:47-57. 2017
The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.. 36:11704-11715. 2016
Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation.. 36:7877-85. 2016
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain.. 36:7364-74. 2016
Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors.. 36:6287-96. 2016
β-Amyloid Deposition Is Associated with Decreased Right Prefrontal Activation during Task Switching among Cognitively Normal Elderly.. 36:1962-70. 2016
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis.. 36:1871-8. 2016
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.. 35:11514-31. 2015
Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.. 35:8107-17. 2015
A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.. 35:6265-76. 2015
Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity.. 35:1781-91. 2015
microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain.. 35:14717-26. 2015
Ganglioside regulation of AMPA receptor trafficking.. 34:13246-58. 2014
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.. 34:12368-78. 2014
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.. 34:9096-106. 2014
Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.. 34:5882-94. 2014
Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults.. 34:5200-10. 2014
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.. 34:3826-40. 2014
Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.. 34:7281-92. 2014
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.. 33:16016-32. 2013
Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex.. 33:14908-20. 2013
An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.. 33:12300-5. 2013
Ventromedial prefrontal cortex encodes emotional value.. 33:11032-9. 2013
Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.. 33:3765-79. 2013
Antisense reduction of tau in adult mice protects against seizures.. 33:12887-97. 2013
Neuronal clearance of amyloid-β by endocytic receptor LRP1.. 33:19276-83. 2013
The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy.. 33:17553-9. 2013
Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults.. 32:16233-42. 2012
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.. 32:16503-9. 2012
Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease.. 32:12396-405. 2012
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.. 32:11390-5. 2012
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.. 32:11082-94. 2012
Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.. 32:10674-85. 2012
The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).. 32:8817-30. 2012
G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.. 32:5440-53. 2012
Neural mechanisms of object naming and word comprehension in primary progressive aphasia.. 32:4848-55. 2012
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.. 32:3877-86. 2012
P2X4 receptors influence inflammasome activation after spinal cord injury.. 32:3058-66. 2012
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.. 32:15181-92. 2012
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.. 32:13587-96. 2012
Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain.. 32:4334-40. 2012
Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression.. 32:8890-9. 2012
Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults.. 31:17680-8. 2011
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.. 31:16269-78. 2011
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke.. 31:12992-3001. 2011
Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain.. 31:12533-42. 2011
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy.. 31:4124-36. 2011
Anatomy of language impairments in primary progressive aphasia.. 31:3344-50. 2011
RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration.. 31:3186-96. 2011
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.. 31:979-91. 2011
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.. 31:9513-25. 2011
Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.. 31:7049-59. 2011
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.. 31:15861-9. 2011
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.. 31:18007-12. 2011
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.. 31:13110-7. 2011
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.. 31:11328-37. 2011
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.. 31:16507-16. 2011
Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia.. 30:16845-54. 2010
Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.. 30:16160-9. 2010
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.. 30:15374-82. 2010
Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis.. 30:5866-75. 2010
A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.. 30:1798-809. 2010
Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.. 30:11537-47. 2010
RET signaling is required for survival and normal function of nonpeptidergic nociceptors.. 30:3983-94. 2010
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.. 30:10220-32. 2010
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).. 29:15846-50. 2009
Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.. 29:15134-44. 2009
The dorsomedial striatum reflects response bias during learning.. 29:14891-902. 2009
Disruption of functional connectivity in clinically normal older adults harboring amyloid burden.. 29:12686-94. 2009
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.. 29:11257-62. 2009
A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.. 29:10072-80. 2009
Dynamic encoding of action selection by the medial striatum.. 29:3148-59. 2009
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.. 29:1987-97. 2009
Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.. 29:10706-14. 2009
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis.. 29:4252-62. 2009
BRI2 (ITM2b) inhibits Abeta deposition in vivo.. 28:6030-6. 2008
A molecular platform in neurons regulates inflammation after spinal cord injury.. 28:3404-14. 2008
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.. 28:3384-91. 2008
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing.. 28:5159-68. 2008
Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice.. 28:7891-9. 2008
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition.. 28:13542-50. 2008
Neurturin-mediated ret activation is required for retinal function.. 28:4123-35. 2008
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.. 28:14156-64. 2008
The roles of kinases in familial Parkinson's disease.. 27:11865-8. 2007
Abeta40 inhibits amyloid deposition in vivo.. 27:627-33. 2007
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.. 26:11923-8. 2006
Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.. 26:10222-31. 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.. 26:10068-78. 2006
Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting.. 26:7870-4. 2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.. 26:3685-96. 2006
Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.. 26:981-90. 2006
Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.. 26:535-41. 2006
Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.. 26:13548-55. 2006
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.. 26:10939-48. 2006
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.. 25:10180-7. 2005
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.. 25:7968-78. 2005
Bcl-x is required for proper development of the mouse substantia nigra.. 25:6721-8. 2005
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.. 25:5544-52. 2005
Redundancy and synergy of neuronal ensembles in motor cortex.. 25:4207-16. 2005
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.. 25:2002-9. 2005
Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.. 25:2376-85. 2005
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.. 25:629-36. 2005
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.. 25:2803-10. 2005
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.. 25:11495-503. 2005
Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice.. 25:10414-9. 2005
Interactions of postsynaptic density-95 and the NMDA receptor 2 subunit control calpain-mediated cleavage of the NMDA receptor.. 24:11035-45. 2004
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.. 24:10963-73. 2004
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.. 24:10040-6. 2004
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.. 24:5439-44. 2004
Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.. 24:257-68. 2004
Selective activation induced cleavage of the NR2B subunit by calpain.. 23:11322-31. 2003
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.. 23:8532-8. 2003
Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.. 23:7889-96. 2003
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.. 23:8844-53. 2003
Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents.. 22:7746-53. 2002
Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.. 22:4897-905. 2002
Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.. 22:10083-7. 2002
Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.. 22:1054-62. 2002
Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia.. 22:455-63. 2002
Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.. 21:8198-209. 2001
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.. 21:4987-95. 2001
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.. 21:-. 2001
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase.. 20:8005-11. 2000
Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons.. 19:3791-800. 1999
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.. 19:9192-200. 1999
Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity.. 19:64-71. 1999
Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity.. 18:2040-55. 1998
NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons.. 18:1725-34. 1998
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.. 17:9415-22. 1997
Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase.. 17:4633-41. 1997
Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons.. 17:3455-66. 1997
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice.. 16:2479-87. 1996
An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture.. 15:5098-105. 1995
Neuronal regeneration enhances the expression of the immunophilin FKBP-12.. 15:2985-94. 1995
LTP saturation and spatial learning disruption: effects of task variables and saturation levels.. 14:5793-806. 1994
Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats.. 14:5202-22. 1994
Gases as biological messengers: nitric oxide and carbon monoxide in the brain.. 14:5147-59. 1994
Phosphoinositide second messenger system is enriched in striosomes: immunohistochemical demonstration of inositol 1,4,5-trisphosphate receptors and phospholipase C beta and gamma in primate basal ganglia.. 13:3300-8. 1993
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.. 13:3051-63. 1993
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.. 13:2651-61. 1993
Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain.. 13:2001-12. 1993
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.. 12:4045-55. 1992
Secretin and vasoactive intestinal peptide activate tyrosine hydroxylase in sympathetic nerve endings.. 9:160-6. 1989
D-1 dopamine receptors in the rat brain: a quantitative autoradiographic analysis.. 6:2352-65. 1986
A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis 2013

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The Journal of neuroscience : the official journal of the Society for Neuroscience Journal

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