The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.
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Overview
publication date
- February 23, 2021
published in
- Neurobiology of disease Journal
has subject area
- Animals
- Behavior, Animal
- Brain
- Dopaminergic Neurons
- Endosomes
- Gene-Environment Interaction
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Motor Activity
- Neostriatum
- Open Field Test
- Oxidative Stress
- Parkinsonian Disorders
- Protein Aggregates
- Rats
- Solvents
- Substantia Nigra
- Trichloroethylene
- alpha-Synuclein