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Felipe A. Jain, MD
Positions
- Assistant Professor, Harvard Medical School
- Psychiatrist, Massachusetts General Hospital
Location
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Boston, MA 02114
United States
I study virtual, smartphone and in-person delivery of psychotherapy to aging adults with a particular emphasis on family dementia caregivers. Recent work has focused on 4-week Mentalizing Imagery Therapy (MIT), which teaches mindfulness and guided imagery practices that facilitate understanding of self and others. Results in caregivers have included reductions in depression and anxiety, and increases in well-being and happiness. My work has been the first to identify a replicable brain biomarker of improvement in depression in caregivers: connectivity increase between dorsolateral prefrontal cortex and emotion regulation regions. Current projects include delivering MIT skills via smartphone supported by virtual groups to English and Spanish language caregivers, and estimating behavioral and mood changes using passive smartphone and wearable sensors (digital phenotyping).
Clinical Disciplines
Beeson awardee
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Affiliation
Publications
Selected Publications
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article
- Family dementia caregivers with suicidal ideation improve with mentalizing imagery therapy: Results from a pilot study.. Journal of affective disorders reports. 2024
- Effectiveness of Mindful Self-Compassion Training Supported by Online Peer Groups in China: A Pilot Study.. Alternative therapies in health and medicine. 29:170-177. 2023
- Virtual mentalizing imagery therapy for Spanish language Latino family dementia caregivers: A feasibility and acceptability study.. Frontiers in psychology. -. 2023
- Recruitment and Retention in Remote Research: Learnings From a Large, Decentralized Real-world Study.. JMIR formative research. 6:-. 2022
- How family dementia caregivers perceive benefits of a 4-week Mentalizing Imagery Therapy program: a pilot study.. Professional psychology, research and practice. 53:494-503. 2022
- Quantifying and addressing the impact of measurement error in network models.. Behaviour research and therapy. -. 2022
- Mentalizing imagery therapy to augment skills training for dementia caregivers: Protocol for a randomized, controlled trial of a mobile application and digital phenotyping.. Contemporary clinical trials. -. 2022
- Four-Week Mentalizing Imagery Therapy for Family Dementia Caregivers: A Randomized Controlled Trial with Neural Circuit Changes.. Psychotherapy and psychosomatics. 91:1-10. 2022
- Meditative and Mindfulness-Focused Interventions in Neurology: Principles, Science, and Patient Selection.. Seminars in neurology. 42:123-135. 2022
- Olfactory Function and Markers of Brain Pathology in Non-Demented Individuals with Autosomal Dominant Alzheimer's Disease.. Journal of Alzheimer's disease : JAD. 88:721-729. 2022
- Use of Staging Models for Treatment-Resistant Depression Is Not Helpful in Predicting Nonresponse to Acute Intravenous Ketamine Treatment.. Journal of clinical psychopharmacology. 42:140-145. 2022
- Mentalizing imagery therapy for depressed family dementia caregivers: Feasibility, clinical outcomes and brain connectivity changes.. Journal of affective disorders reports. 2021
- Diminished Age-Related Decline of the Amygdala in Long-Term Meditation Practitioners.. Psychosomatic medicine. 83:650-654. 2021
- Long-term outcome in outpatients with depression treated with acute and maintenance intravenous ketamine: A retrospective chart review.. Journal of affective disorders. 660-666. 2020
- Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis.. Psychoneuroendocrinology. -. 2019
- Longer-term open-label study of adjunctive riluzole in treatment-resistant depression.. Journal of affective disorders. 102-108. 2019
- Grief, Mindfulness and Neural Predictors of Improvement in Family Dementia Caregivers.. Frontiers in human neuroscience. -. 2019
- Mentalizing Imagery Therapy Mobile App to Enhance the Mood of Family Dementia Caregivers: Feasibility and Limited Efficacy Testing.. JMIR aging. 2:-. 2019
- Mentalizing Imagery Therapy: Theory and case series of imagery and mindfulness techniques to understand self and others.. Mindfulness. 11:153-165. 2018
- Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.. Journal of affective disorders. 193-200. 2017
- Assessment of the Hispanic Cognitively Impaired Elderly Patient.. Neurologic clinics. 35:207-229. 2017
- Oxidative stress, inflammation and treatment response in major depression.. Psychoneuroendocrinology. 197-205. 2016
- Escitalopram but not placebo modulates brain rhythmic oscillatory activity in the first week of treatment of Major Depressive Disorder.. Journal of psychiatric research. 174-183. 2016
- Neurophysiologic Correlates of Headache Pain in Subjects With Major Depressive Disorder.. Clinical EEG and neuroscience. 48:159-167. 2016
- A role for profiles of patient-specific depression characteristics and socioeconomic factors in the prediction of antidepressant treatment outcome.. The Journal of clinical psychiatry. 76:-. 2015
- Critical analysis of the efficacy of meditation therapies for acute and subacute phase treatment of depressive disorders: a systematic review.. Psychosomatics. 56:140-52. 2014
- Heart rate variability and treatment outcome in major depression: a pilot study.. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 93:204-10. 2014
- Feasibility of central meditation and imagery therapy for dementia caregivers.. International journal of geriatric psychiatry. 29:870-6. 2014
- Predictive socioeconomic and clinical profiles of antidepressant response and remission.. Depression and anxiety. 30:624-30. 2013
- Rapid response of major depressive disorder and comorbid eating disorder NOS to a novel meditation intervention.. Psychosomatics. 53:401-2. 2012
- Individual risk profiles for postoperative delirium after joint replacement surgery.. Psychosomatics. 52:410-6. 2011
- Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient.. Brain research. 15-23. 2009
- Prospective assessment of stereotactic ablative surgery for intractable major depression.. Biological psychiatry. 64:449-54. 2008
- Neonatal anterior cervical arachnoid cyst: case report and review of the literature.. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 24:965-70. 2008
- IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin.. Experimental and molecular pathology. 76:205-11. 2004
- Epinephrine promotes pulmonary angiitis: evidence for a beta1-adrenoreceptor-mediated mechanism.. American journal of physiology. Lung cellular and molecular physiology. 285:L232-9. 2003
- IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis.. Experimental and molecular pathology. 72:1-9. 2002
Research
Principal Investigator on
- Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotyping 2020 - 2025
- Mindfulness and guided imagery for depressed family caregivers of patients with Alzheimer's disease and related dementias: clinical outcomes and neural mechanisms 2016 - 2019