Selected Publications
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article
- The Association Between Accelerated Biological Aging and Cardiovascular Outcomes in Older Adults with Hypertension.. The American journal of medicine. 2024
- A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.. Cell reports. -. 2024
- Role of the National Institute on Aging in Transforming Aging Research Through Geroscience and Gerotherapeutics-50 Years of Innovation.. JAMA internal medicine. 184:1146-1148. 2024
- Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study.. medRxiv : the preprint server for health sciences. 2024
- Rationale and protocol for a safety, tolerability and feasibility randomized, parallel arm, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.. PloS one. 19:-. 2024
- Bringing Geroscience into the Mainstream: From Education to Clinical Practice, What Will It Take?. The journals of gerontology. Series A, Biological sciences and medical sciences. 79. 2024
- Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study.. The journal of nutrition, health & aging. 28:-. 2024
- Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice.. Cell reports. Medicine. 5:-. 2024
- Associations of Lower Extremity Muscle Strength, Area, and Specific Force With Lower Urinary Tract Symptoms in Older Men: The Baltimore Longitudinal Study of Aging.. The journals of gerontology. Series A, Biological sciences and medical sciences. 79. 2024
- A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.. bioRxiv : the preprint server for biology. 2024
- A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.. bioRxiv : the preprint server for biology. 2024
- Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis.. GeroScience. 46:3287-3295. 2024
- A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging.. bioRxiv : the preprint server for biology. 2023
- Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.. medRxiv : the preprint server for health sciences. 2023
- β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.. bioRxiv : the preprint server for biology. 2023
- Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.. Journal of the American College of Cardiology. 82:631-647. 2023
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:2150-2174. 2023
- Letter to the Editor: Healthy Eating Patterns: A Stealthy Geroscience-Guided Approach to Enhancing the Human Healthspan.. The journal of nutrition, health & aging. 27:238-239. 2023
- Longitudinal Associations between Concurrent Changes in Phenotypic Frailty and Lower Urinary Tract Symptoms among Older Men.. The Journal of frailty & aging. 12:117-125. 2023
- Lower urinary tract symptom severity, urinary bother, and incident life-space mobility restriction among older men.. Journal of the American Geriatrics Society. 71:1093-1104. 2022
- Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.. Aging cell. 21:-. 2022
- Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.. Journal of the American Nutrition Association. 42:1-177. 2022
- Interpreting Geroscience-Guided Biomarker Studies.. JAMA internal medicine. 182:300-302. 2022
- COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study.. BMC psychiatry. 22:-. 2022
- Lower urinary tract symptoms and incident functional limitations among older community-dwelling men.. Journal of the American Geriatrics Society. 70:1082-1094. 2021
- Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy.. JAMA network open. 4:-. 2021
- Outcomes Following Implementation of a Hospital-Wide, Multicomponent Delirium Care Pathway.. Journal of hospital medicine. 16:397-403. 2021
- Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.. Nutrients. 13. 2021
- Genetic Toxicity Studies of the Ketogenic Ester Bis Hexanoyl (R)-1,3-Butanediol.. International journal of toxicology. 40:242-249. 2021
- Toxicological evaluation of the ketogenic ester bis hexanoyl (R)-1,3-butanediol: Subchronic toxicity in Sprague Dawley rats.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. -. 2021
- Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure.. Circulation. Heart failure. 14:-. 2020
- SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.. Nature communications. 11:-. 2020
- In vitro stability and in vivo pharmacokinetics of the novel ketogenic ester, bis hexanoyl (R)-1,3-butanediol.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. -. 2020
- From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience.. GeroScience. 43:1071-1081. 2020
- Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.. Med (New York, N.Y.). 1:43-65. 2020
- Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells.. Cell. 181:1263-1275.e16. 2020
- Collaborative Delirium Prevention in the Age of COVID-19.. Journal of the American Geriatrics Society. 68:947-949. 2020
- Ketogenic diet and adipose tissue inflammation-a simple story? Fat chance!. Nature metabolism. 2:3-4. 2020
- From discoveries in ageing research to therapeutics for healthy ageing.. Nature. 571:183-192. 2019
- Creating the Next Generation of Translational Geroscientists.. Journal of the American Geriatrics Society. 67:1934-1939. 2019
- Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.. Journal of the American Geriatrics Society. 67:428-433. 2019
- Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.. Cell metabolism. 26:523-538.e5. 2017
- Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.. Cell metabolism. 26:547-557.e8. 2017
- β-Hydroxybutyrate: A Signaling Metabolite.. Annual review of nutrition. 51-76. 2017
- Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.. The journals of gerontology. Series A, Biological sciences and medical sciences. 71:1415-1423. 2016
- Strategies and Challenges in Clinical Trials Targeting Human Aging.. The journals of gerontology. Series A, Biological sciences and medical sciences. 71:1424-1434. 2016
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.. eLife. 2016
- Dextromethorphan-Quinidine for Agitation in Alzheimer Disease.. JAMA. 315:-. 2016
- Copyright and Bedside Cognitive Testing: Why We Need Alternatives to the Mini-Mental State Examination.. JAMA internal medicine. 175:1459-60. 2015
- β-hydroxybutyrate: much more than a metabolite.. Diabetes research and clinical practice. 106:173-81. 2014
- SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.. Cell metabolism. 18:920-33. 2013
- Ketone bodies as signaling metabolites.. Trends in endocrinology and metabolism: TEM. 25:42-52. 2013
- Long-term outcomes in elderly survivors of cardiac arrest.. The New England journal of medicine. 368:-. 2013
- Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.. Proceedings of the National Academy of Sciences of the United States of America. 110:6601-6. 2013
- Copyright at the Bedside: Should We Stop the Spread?. Stanford technology law review : STLR : an online high-technology law journal from Stanford Law School. 16:623-655. 2013
- Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.. Science (New York, N.Y.). 339:211-4. 2012
- Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease.. The Journal of biological chemistry. 287:42436-43. 2012
- Mitochondrial sirtuins: regulators of protein acylation and metabolism.. Trends in endocrinology and metabolism: TEM. 23:467-76. 2012
- The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.. DNA repair. 11:488-501. 2012
- Copyright and open access at the bedside.. The New England journal of medicine. 365:2447-9. 2011
- Leriche syndrome.. Journal of general internal medicine. 25:1102-4. 2010
- An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.. PLoS genetics. 4:-. 2008
- Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization.. Gene. 401:12-8. 2007
- Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.. Proceedings of the National Academy of Sciences of the United States of America. 103:9613-8. 2006
- L2L: a simple tool for discovering the hidden significance in microarray expression data.. Genome biology. 6:-. 2005
- Measuring the immeasurable.. Molecular cell. 10:437-9. 2002
- The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.. Molecular and cellular biology. 21:8104-16. 2001