Publications in VIVO

Co-author Network

Co-investigator Network

Thomas A. Rando, MD, PhD

Person

Positions

Director, Broad Stem Cell Research Center, University of California, Los Angeles
Professor, Department of Neurology, University of California, Los Angeles
Professor of Molecular, Cell and Developmental Biology, University of California, Los Angeles

Location

Los Angeles, California

Clinical Disciplines

Neurology

Beeson awardee

Publications
Research
Other
View All

Selected Publications

article
1. A mouse model of volumetric muscle loss and therapeutic scaffold implantation.. Nature protocols. 2024
2. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.. Aging. 16:12955-12976. 2024
3. Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus.. Stem cells (Dayton, Ohio). 42:266-277. 2024
4. Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing.. Nature metabolism. 6:153-168. 2024
5. Scanorama: integrating large and diverse single-cell transcriptomic datasets. Nature Protocols. 2024
6. Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening. Stem Cell Reports. 2024
7. Combinatorial activation of the WNT-dependent fibrogenic program by distinct complement subunits in dystrophic muscle.. EMBO molecular medicine. 15:-. 2023
8. Identification of an adipose tissue-resident pro-preadipocyte population.. Cell reports. 42:-. 2023
9. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity.. Nature reviews. Molecular cell biology. 24:334-354. 2023
10. Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss.. Developmental cell. 58:489-505.e7. 2023
11. Correction to: Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice.. Stem cell reviews and reports. 18:-. 2022
12. Regenerative medicine: postnatal approaches.. The Lancet. Child & adolescent health. 6:654-666. 2022
13. Ageing and rejuvenation of tissue stem cells and their niches.. Nature reviews. Molecular cell biology. 24:45-62. 2022
14. Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice.. Stem cell reviews and reports. 18:2431-2443. 2022
15. ATR activity controls stem cell quiescence via the cyclin F-SCF complex.. Proceedings of the National Academy of Sciences of the United States of America. 119:-. 2022
16. Comparative Effects of Basic Fibroblast Growth Factor Delivery or Voluntary Exercise on Muscle Regeneration after Volumetric Muscle Loss.. Bioengineering (Basel, Switzerland). 9. 2022
17. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling.. Cell metabolism. 34:902-918.e6. 2022
18. RNA-binding proteins direct myogenic cell fate decisions.. eLife. 2022
19. Scalable macroporous hydrogels enhance stem cell treatment of volumetric muscle loss. Biomaterials. 2022
20. Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo.. Stem cell reports. 17:82-95. 2022
21. Asynchronous, contagious and digital aging.. Nature aging. 1:29-35. 2021
22. Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss.. Biomaterials. -. 2021
23. Computational modeling of malignant ascites reveals CCL5-SDC4 interaction in the immune microenvironment of ovarian cancer.. Molecular carcinogenesis. 60:297-312. 2021
24. Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms.. Oncogene. 40:4955-4966. 2021
25. Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery.. Biomaterials. -. 2021
26. Exercise plasma boosts memory and dampens brain inflammation via clusterin.. Nature. 600:494-499. 2021
27. Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist.. Proceedings of the National Academy of Sciences of the United States of America. 118. 2021
28. Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging.. Cold Spring Harbor perspectives in biology. 13. 2021
29. Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells.. Cell stem cell. 28:1323-1334.e8. 2021
30. ARDD 2020: from aging mechanisms to interventions.. Aging. 12:24484-24503. 2020
31. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.. Nature communications. 11:-. 2020
32. Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field.. Archives of physical medicine and rehabilitation. 101:917-923. 2020
33. Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.. Nature metabolism. 2:307-317. 2020
34. Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.. Proceedings of the National Academy of Sciences of the United States of America. 117:30907-30917. 2020
35. Stem cell therapy for muscular dystrophies.. The Journal of clinical investigation. 130:5652-5664. 2020
36. Chronic inflammation in the etiology of disease across the life span.. Nature medicine. 25:1822-1832. 2019
37. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.. Journal of the American Geriatrics Society. 67:428-433. 2019
38. Adult stem cells and regenerative medicine-a symposium report.. Annals of the New York Academy of Sciences. 1462:27-36. 2019
39. Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function.. Science (New York, N.Y.). 366:734-738. 2019
40. Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration.. The Journal of physiology. 598:317-329. 2019
41. Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle.. Cell reports. 27:2029-2035.e5. 2019
42. Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling.. Cell stem cell. 24:213-225. 2019
43. Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration.. Communications biology. -. 2019
44. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.. Aging cell. 18:-. 2019
45. The regenerative rehabilitation collection: a forum for an emerging field.. NPJ Regenerative medicine. -. 2018
46. Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.. Cell stem cell. 22:306-309. 2018
47. A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.. Developmental cell. 46:135-143. 2018
48. Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.. Nature communications. 2018
49. Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle.. Molecular therapy. Methods & clinical development. 144-155. 2018
50. Biomechanics show stem cell necessity for effective treatment of volumetric muscle loss using bioengineered constructs.. NPJ Regenerative medicine. -. 2018
51. Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.. Nature communications. 9:-. 2018
52. Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells.. Cell stem cell. 23:544-556.e4. 2018
53. Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.. Cell stem cell. 22:177-190.e7. 2018
54. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.. Science (New York, N.Y.). 359:1277-1283. 2018
55. Rehabilitative exercise and spatially patterned nanofibrillar scaffolds enhance vascularization and innervation following volumetric muscle loss.. NPJ Regenerative medicine. -. 2018
56. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.. Nature. 2018
57. mdx. Proceedings of the National Academy of Sciences of the United States of America. 115:7741-7746. 2018
58. Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.. Aging cell. 16:518-528. 2017
59. Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss.. Nature communications. -. 2017
60. Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c.. Proceedings of the National Academy of Sciences of the United States of America. 114:E3071-E3080. 2017
61. Fleeting factors, turning back time.. Nature biotechnology. 35:218-220. 2017
62. Interaction between epigenetic and metabolism in aging stem cells.. Current opinion in cell biology. 1-7. 2017
63. Macrophage-released ADAMTS1 promotes muscle stem cell activation.. Nature communications. 8:-. 2017
64. Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation.. Scientific reports. 7:-. 2017
65. Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.. Proceedings of the National Academy of Sciences of the United States of America. 114:E8996-E9005. 2017
66. The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.. NPJ Regenerative medicine. -. 2017
67. Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo.. Cell reports. 21:1994-2004. 2017
68. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.. Cell stem cell. 21:806-818.e5. 2017
69. An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy.. Nature biotechnology. 34:752-9. 2016
70. Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis.. Nature. 540:276-279. 2016
71. UTX in muscle regeneration--the right dose and the right time.. The Journal of clinical investigation. 2016
72. Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells.. Stem cell reports. 5:621-32. 2015
73. Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting.. Nature protocols. 10:1612-24. 2015
74. Mimicking the niche: cytokines expand muscle stem cells.. Cell research. 25:761-2. 2015
75. Stem cells and healthy aging.. Science (New York, N.Y.). 350:1199-204. 2015
76. Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.. Annual review of biomedical engineering. 217-42. 2015
77. The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction.. Molecular medicine (Cambridge, Mass.). 579-89. 2015
78. A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice.. Science translational medicine. 6:-. 2014
79. Alive and well? Exploring disease by studying lifespan.. Current opinion in genetics & development. 33-40. 2014
80. FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal.. Stem cell reports. 2:414-26. 2014
81. Geroscience: linking aging to chronic disease.. Cell. 159:709-13. 2014
82. H3K4me3 breadth is linked to cell identity and transcriptional consistency.. Cell. 158:673-88. 2014
83. Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.. The EMBO journal. 33:2782-97. 2014
84. Lineage of origin in rhabdomyosarcoma informs pharmacological response.. Genes & development. 28:1578-91. 2014
85. Regenerative medicine: Of fish and men.. Nature chemical biology. 10:91-2. 2014
86. Stem cells as vehicles for youthful regeneration of aged tissues.. The journals of gerontology. Series A, Biological sciences and medical sciences. S39-42. 2014
87. Translational strategies and challenges in regenerative medicine.. Nature medicine. 20:814-21. 2014
88. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).. Nature. 510:393-6. 2014
89. A sexy spin on nonrandom chromosome segregation.. Cell stem cell. 12:641-3. 2013
90. All's well that ends well: alternative polyadenylation and its implications for stem cell biology.. Current opinion in cell biology. 25:222-32. 2013
91. Assessment of disease activity in muscular dystrophies by noninvasive imaging.. The Journal of clinical investigation. 123:2298-305. 2013
92. Cardiac aging and rejuvenation--a sense of humors?. The New England journal of medicine. 2013
93. Cardiac aging and rejuvenation--a sense of humors?. The New England journal of medicine. 369:575-6. 2013
94. Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.. Cell reports. 4:189-204. 2013
95. Collagen VI regulates satellite cell self-renewal and muscle regeneration.. Nature communications. 2013
96. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis.. Cell reports. 4:477-91. 2013
97. Guest editorial: emergent themes from second annual symposium on regenerative rehabilitation, Pittsburgh, Pennsylvania.. Journal of rehabilitation research and development. 2013
98. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity.. Aging cell. 2013
99. Molecular regulation of stem cell quiescence.. Nature reviews. Molecular cell biology. 14:329-40. 2013
100. Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells.. Developmental biology. 379:195-207. 2013
101. Numb-deficient satellite cells have regeneration and proliferation defects.. Proceedings of the National Academy of Sciences of the United States of America. 2013
102. The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.. PloS one. 2013
103. The ins and outs of aging and longevity.. Annual review of physiology. 617-9. 2013
104. The mortal strand hypothesis: non-random chromosome inheritance and the biased segregation of damaged DNA.. Seminars in cell & developmental biology. 24:653-60. 2013
105. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.. Cell. 2013
106. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.. Cell. 148:46-57. 2012
107. Alternative polyadenylation mediates microRNA regulation of muscle stem cell function.. Cell stem cell. 10:327-36. 2012
108. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches.. Cell cycle (Georgetown, Tex.). 2012
109. Losartan improves adipose tissue-derived stem cell niche by inhibiting transforming growth factor-β and fibrosis in skeletal muscle injury.. Cell transplantation. 2012
110. Maintenance of muscle stem-cell quiescence by microRNA-489.. Nature. 482:524-8. 2012
111. Notch signaling is necessary to maintain quiescence in adult muscle stem cells.. Stem cells (Dayton, Ohio). 30:232-42. 2012
112. Recent advances in the pathogenesis and treatment of neuromuscular diseases.. Current opinion in neurology. 2012
113. Sprouting a new take on stem cell aging.. The EMBO journal. 31:4103-5. 2012
114. The place of genetics in ageing research.. Nature reviews. Genetics. 2012
115. Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.. Cell stem cell. 2012
116. Emerging models and paradigms for stem cell ageing.. Nature cell biology. 2011
117. Manifestations and mechanisms of stem cell aging.. The Journal of cell biology. 193:257-66. 2011
118. Stem cell ageing and non-random chromosome segregation.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 366:85-93. 2011
119. The ageing systemic milieu negatively regulates neurogenesis and cognitive function.. Nature. 477:90-4. 2011
120. Heterogeneity in the muscle satellite cell population.. Seminars in cell & developmental biology. 21:845-54. 2010
121. Taf1 regulates Pax3 protein by monoubiquitination in skeletal muscle progenitors.. Molecular cell. 40:749-61. 2010
122. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.. Developmental biology. 335:93-105. 2009
123. Biomarker system for studying muscle, stem cells, and cancer in vivo.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009
124. Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides.. Nucleic acids research. 37:7468-82. 2009
125. Epigenetics and aging.. Experimental gerontology. 2009
126. Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.. Molecular biology of the cell. 20:3422-35. 2009
127. Preventing oxidative stress: a new role for XBP1.. Cell death and differentiation. 2009
128. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.. Cell stem cell. 2:50-9. 2008
129. Get personal with gene therapy for muscular dystrophy.. The Lancet. Neurology. 2008
130. Stem cell review series: aging of the skeletal muscle stem cell niche.. Aging cell. 7:590-8. 2008
131. Technology insight: therapy for Duchenne muscular dystrophy-an opportunity for personalized medicine?. Nature clinical practice. Neurology. 2008
132. Tissue ageing: do insights into molecular mechanisms of ageing lead to new therapeutic strategies?. Experimental gerontology. 43:603-604. 2008
133. Turning back time: reversing tissue pathology to enhance stem cell engraftment.. Cell stem cell. 3:232-4. 2008
134. [Proteasomal degradation of Pax3 in skeletal muscle progenitors: one ubiquitin does the trick!].. Medecine sciences : M/S. 24:31-3. 2008
135. Ageing: from stem to stern.. Nature. 2007
136. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.. PLoS biology. 2007
137. High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.. PLoS biology. 5:-. 2007
138. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.. Science (New York, N.Y.). 2007
139. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.. Science (New York, N.Y.). 317:807-10. 2007
140. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging.. Stem cell reviews. 2007
141. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging.. Stem cell reviews. 3:226-37. 2007
142. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.. Cell. 2007
143. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.. Cell. 130:349-62. 2007
144. The immortal strand hypothesis: segregation and reconstruction.. Cell. 2007
145. The immortal strand hypothesis: segregation and reconstruction.. Cell. 129:1239-43. 2007
146. Altered caveolin-3 expression disrupts PI(3) kinase signaling leading to death of cultured muscle cells.. Experimental cell research. 2006
147. Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.. Developmental biology. 2006
148. Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells.. Developmental biology. 293:38-52. 2006
149. Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery.. Human gene therapy. 2006
150. Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery.. Human gene therapy. 17:871-6. 2006
151. Non-viral gene therapy for Duchenne muscular dystrophy: progress and challenges.. Biochimica et biophysica acta. 2006
152. Non-viral gene therapy for Duchenne muscular dystrophy: progress and challenges.. Biochimica et biophysica acta. 1772:263-71. 2006
153. Prognostic value of telomere length: the long and short of it.. Annals of neurology. 2006
154. Stem cells, ageing and the quest for immortality.. Nature. 2006
155. Aging, stem cells and tissue regeneration: lessons from muscle.. Cell cycle (Georgetown, Tex.). 2005
156. Aging, stem cells and tissue regeneration: lessons from muscle.. Cell cycle (Georgetown, Tex.). 4:407-10. 2005
157. Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.. Proceedings of the National Academy of Sciences of the United States of America. 2005
158. Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.. Proceedings of the National Academy of Sciences of the United States of America. 103:419-24. 2005
159. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs.. The Journal of biological chemistry. 2005
160. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs.. The Journal of biological chemistry. 280:18981-9. 2005
161. Rejuvenation of aged progenitor cells by exposure to a young systemic environment.. Nature. 2005
162. Rejuvenation of aged progenitor cells by exposure to a young systemic environment.. Nature. 433:760-4. 2005
163. Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment.. Trends in cell biology. 2005
164. The adult muscle stem cell comes of age.. Nature medicine. 2005
165. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis.. Seminars in cell & developmental biology. 2005
166. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis.. Seminars in cell & developmental biology. 16:612-22. 2005
167. Artificial sweeteners--enhancing glycosylation to treat muscular dystrophies.. The New England journal of medicine. 351:1254-6. 2004
168. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.. Cell. 2004
169. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.. Cell. 119:543-54. 2004
170. Strand bias in oligonucleotide-mediated dystrophin gene editing.. Human molecular genetics. 14:221-33. 2004
171. The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreading.. Journal of cell science. 117:4469-79. 2004
172. A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes.. Journal of cell science. 116:4739-49. 2003
173. Notch-mediated restoration of regenerative potential to aged muscle.. Science (New York, N.Y.). 2003
174. Notch-mediated restoration of regenerative potential to aged muscle.. Science (New York, N.Y.). 302:1575-7. 2003
175. Restoration of dystrophin expression in mdx muscle cells by chimeraplast-mediated exon skipping.. Human molecular genetics. 12:1087-99. 2003
176. Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides.. Human gene therapy. 13:707-18. 2002
177. Gene delivery to muscle.. Current protocols in human genetics. -. 2002
178. Oligonucleotide-mediated gene therapy for muscular dystrophies.. Neuromuscular disorders : NMD. S55-60. 2002
179. Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.. Journal of cell science. 115:2151-63. 2002
180. The modulation of cellular susceptibility to oxidative stress: protective and destructive actions of Cu,Zn-superoxide dismutase.. Neurobiology of disease. 10:234-46. 2002
181. The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.. Developmental cell. 3:397-409. 2002
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1. Exercise and angiotensin receptor blockade enhance recovery after orthopaedic trauma in mice by decreasing pain and improving muscle regeneration 2019