Proceedings of the National Academy of Sciences of the United States of America

publication venue for

Association of cumulative loneliness with all-cause mortality among middle-aged and older adults in the United States, 1996 to 2019.. 120:-. 2023
In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.. 120:-. 2023
The contributions of rare inherited and polygenic risk to ASD in multiplex families.. 120:-. 2023
Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.. 120:-. 2023
Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes.. 120:-. 2023
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality.. 120:-. 2023
Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms.. 120:-. 2023
Social Frailty Index: Development and validation of an index of social attributes predictive of mortality in older adults.. 120:-. 2023
Brain aerobic glycolysis and resilience in Alzheimer disease.. 120:-. 2023
Cardiac progenitors instruct second heart field fate through Wnts.. 120:-. 2023
microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.. 120:-. 2023
Trends in inequalities in the prevalence of dementia in the United States.. 119:-. 2022
Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study.. 119:-. 2022
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy.. 119:-. 2022
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.. 119:-. 2022
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.. 119. 2022
ATR activity controls stem cell quiescence via the cyclin F-SCF complex.. 119:-. 2022
Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.. 118. 2021
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.. 118. 2021
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.. 118. 2021
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion.. 118. 2021
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist.. 118. 2021
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.. 117:32606-32616. 2020
Network interventions for managing the COVID-19 pandemic and sustaining economy.. 117:30285-30294. 2020
Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.. 117:30907-30917. 2020
In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.. 116:10156-10161. 2019
Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.. 115:10160-10165. 2018
Statistical tests and identifiability conditions for pooling and analyzing multisite datasets.. 115:1481-1486. 2018
Effects of rapamycin on growth hormone receptor knockout mice.. 115:E1495-E1503. 2018
Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma.. 115:E498-E505. 2018
The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health.. 115:702-707. 2018
Universal method for robust detection of circadian state from gene expression.. 115:E9247-E9256. 2018
mdx. 115:7741-7746. 2018
Humanized mouse model supports development, function, and tissue residency of human natural killer cells.. 114:E9626-E9634. 2017
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.. 114:E9665-E9674. 2017
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.. 114:11524-11529. 2017
Distribution of lifetime nursing home use and of out-of-pocket spending.. 114:9838-9842. 2017
Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.. 114:E4996-E5005. 2017
Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c.. 114:E3071-E3080. 2017
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.. 114:E4676-E4685. 2017
Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.. 114:E8996-E9005. 2017
FEF inactivation with improved optogenetic methods.. 113:E7297-E7306. 2016
Genetic variants linked to education predict longevity.. 113:13366-13371. 2016
Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.. 113:E6535-E6544. 2016
Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study.. 113:E6335-E6342. 2016
Morphometricity as a measure of the neuroanatomical signature of a trait.. 113:E5749-56. 2016
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.. 113:10186-91. 2016
Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.. 113:E5212-21. 2016
Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.. 113:E4630-8. 2016
Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.. 113:7148-53. 2016
Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis.. 112:E6535-43. 2015
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.. 112:11696-701. 2015
Quantification of biological aging in young adults.. 112:E4104-10. 2015
Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.. 112:2888-93. 2015
Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.. 112:E881-90. 2015
Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.. 112:11965-70. 2015
Fear and C-reactive protein cosynergize annual pulse increases in healthy adults.. 112:E467-71. 2014
Direct measurements of methane emissions from abandoned oil and gas wells in Pennsylvania.. 111:18173-7. 2014
MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma.. 111:12550-5. 2014
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.. 111:10732-7. 2014
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.. 111:10209-14. 2014
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.. 111:4940-5. 2014
Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone.. 111:1545-50. 2014
Network analysis reveals multiscale controls on streamwater chemistry.. 111:7030-5. 2014
Proteopathic tau seeding predicts tauopathy in vivo.. 111:E4376-85. 2014
Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease.. 110:E4502-9. 2013
What is a representative brain? Neuroscience meets population science.. 110:17615-22. 2013
Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study.. 110:17149-53. 2013
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.. 110:6601-6. 2013
Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.. 110:E1222-31. 2013
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.. 110:E448-57. 2013
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.. 110:E1807-16. 2013
Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring.. 110:E4601-10. 2013
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.. 109:21486-91. 2012
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4.. 109:E3687-95. 2012
MicroRNA-223 is neuroprotective by targeting glutamate receptors.. 109:18962-7. 2012
Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.. 109:11294-9. 2012
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.. 109:8212-7. 2012
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.. 110:300-5. 2012
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.. 109:15502-7. 2012
Volcanic ash layers illuminate the resilience of Neanderthals and early modern humans to natural hazards.. 109:13532-7. 2012
Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF.. 108:E924-33. 2011
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.. 108:14103-8. 2011
Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis.. 108:17159-64. 2011
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.. 108:19054-9. 2011
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.. 107:16691-6. 2010
Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons.. 107:16661-6. 2010
Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling.. 107:4669-74. 2010
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.. 107:378-83. 2009
Reversal of long-term dendritic spine alterations in Alzheimer disease models.. 106:16877-82. 2009
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.. 106:9403-8. 2009
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.. 106:7607-12. 2009
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.. 106:4900-5. 2009
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.. 106:2897-902. 2009
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.. 106:12145-50. 2009
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.. 105:10595-600. 2008
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.. 105:2681-6. 2008
Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation.. 105:2181-6. 2008
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.. 105:8050-4. 2008
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.. 104:14807-12. 2007
Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity.. 104:10673-8. 2007
Molecular markers of early Parkinson's disease based on gene expression in blood.. 104:955-60. 2007
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.. 103:18314-9. 2006
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.. 103:18787-92. 2006
Poly(ADP-ribose) (PAR) polymer is a death signal.. 103:18308-13. 2006
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.. 103:17378-83. 2006
Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.. 103:9613-8. 2006
Butyrylcholinesterase attenuates amyloid fibril formation in vitro.. 103:8628-33. 2006
Neuroprotection by pharmacologic blockade of the GAPDH death cascade.. 103:3887-9. 2006
Cortical signatures of noun and verb production.. 103:1644-9. 2006
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity.. 103:14919-24. 2006
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.. 102:18676-81. 2005
Huntington's disease and neurogenesis: FGF-2 to the rescue?. 102:17889-90. 2005
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.. 102:16842-7. 2005
Regulatable atrial natriuretic peptide gene therapy for hypertension.. 102:13789-94. 2005
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.. 102:8472-7. 2005
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.. 102:2162-7. 2005
Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.. 103:419-24. 2005
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.. 101:17699-704. 2004
Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons.. 101:14264-9. 2004
Loss of locus coeruleus neurons and reduced startle in parkin null mice.. 101:10744-9. 2004
Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study.. 101:5512-7. 2004
Identification and analysis of plasticity-induced late-response genes.. 101:2145-50. 2004
Disruption of Ixodes scapularis anticoagulation by using RNA interference.. 101:1141-6. 2004
Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.. 101:769-74. 2004
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein.. 101:1075-80. 2004
Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).. 101:647-52. 2003
Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens.. 100:12889-94. 2003
Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.. 100:10540-5. 2003
Telomere attrition and Chk2 activation in human heart failure.. 100:5378-83. 2003
Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.. 100:4784-9. 2003
Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species.. 100:2700-5. 2003
Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.. 100:283-8. 2002
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.. 99:13217-21. 2002
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.. 99:8968-73. 2002
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.. 99:6334-9. 2002
Interactions between thalamic and cortical rhythms during semantic memory recall in human.. 99:6440-3. 2002
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.. 99:4697-702. 2002
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.. 99:3866-71. 2002
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.. 99:10843-8. 2002
Functional MRI detection of pharmacologically induced memory impairment.. 99:455-60. 2001
FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle.. 98:2425-30. 2001
Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase.. 98:1277-81. 2001
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.. 98:1970-5. 2001
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.. 97:13354-9. 2000
Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism.. 97:8617-22. 2000
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.. 97:436-41. 2000
Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity.. 96:12418-23. 1999
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.. 96:5774-9. 1999
Nitric oxide synthase in cardiac sarcoplasmic reticulum.. 96:657-62. 1999
Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras.. 95:5773-8. 1998
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.. 94:10762-7. 1997
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.. 94:2676-80. 1997
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.. 93:9223-8. 1996
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.. 93:6770-4. 1996
Stimulation of new bone formation by direct transfer of osteogenic plasmid genes.. 93:5753-8. 1996
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.. 93:5037-42. 1996
Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase.. 93:4839-44. 1996
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.. 93:4565-71. 1996
Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression.. 92:6823-7. 1995
Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.. 91:4214-8. 1994
Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.. 91:3191-5. 1994
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.. 90:9808-12. 1993
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.. 90:9513-7. 1993
Characterization of distinct functional domains of transforming growth factor beta.. 90:8628-32. 1993
Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.. 90:3256-9. 1993
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.. 88:7797-801. 1991
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.. 88:6368-71. 1991
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.. 85:1227-31. 1988
Both the 25-kDa and 50-kDa domains in myosin subfragment 1 are close to the reactive thiols.. 83:6392-6. 1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.. 83:6631-5. 1986
Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence 2017
Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain 2013
ATP-sensitive potassium channel (KATP)-dependent regulation of cardiotropic viral infections 2011
A genetic screen to isolate type III effectors translocated into pepper cells during Xanthomonas infection 2004

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